Short Decsription
Facilitate CYP3A4 detection using this ready-to-deploy IHC solution, encompassing all necessary reagents from antigen retrieval to slide preparation.
Description
Cytochrome P450 3A (CYP3A) enzymes are essential in the detoxification of xenobiotics and the metabolism of over half of all pharmaceuticals. CYP3A activity influences drug absorption and clearance, with expression levels varying across tissues like the liver, intestine, kidney, and brain. In response to systemic infections, such as lipopolysaccharide (LPS) exposure, CYP3A expression can be downregulated, particularly in the liver, affecting drug metabolism.
Features
Ready to use
High Sensitivity Streptavidin (HSS) increases detection sensitivity
Suitable for tissue sections & cytospin preparations
Pre-diluted reagents minimize hands-on time
Optimizes mouse, rabbit, rat, goat, or sheep IgG primary antibody staining
Analytical Method
Immunohistochemistry
Datasheet