OncoIHC™ TDP-43 Ready-To-Use IHC Kit (CAT#: ITS-1122-ZP4694)

For the effective localization of TDP43, this integrated IHC kit delivers a complete solution. Its ready-to-apply reagents, covering all stages from antigen retrieval to slide preparation, streamline the workflow, enabling researchers to obtain accurate and reproducible IHC results.

The TARDBP gene encodes TDP-43, a protein initially identified as a repressor of HIV-1 transcription by binding TAR DNA. TDP-43 also binds RNA and plays a role in transcriptional repression, translational regulation, and pre-mRNA splicing, including the regulation of CFTR gene splicing. Hyperphosphorylated, ubiquitinated, and cleaved forms of TDP-43, known as pathological TDP-43, are implicated in diseases like ALS and FTLD-U. Recently, TDP-43 has been linked to triple-negative breast cancer (TNBC) and may serve as a target for diagnosis and drug design.

Ready to use
High Sensitivity Streptavidin (HSS) increases detection sensitivity
Suitable for tissue sections & cytospin preparations
Pre-diluted reagents minimize hands-on time
Optimizes mouse, rabbit, rat, goat, or sheep IgG primary antibody staining

IHC

TDP-43

Human, Mouse, Rat

Immunohistochemistry

FFPE tissue