PathFinder™ Ranibizumab Bioassay Kit, 2-plate (CAT#: IOC-ZP435)

The PathFinder™ Dimerization Bioassay detects ligand induced dimerization of two subunits of a receptor-dimer pair. The cells have been engineered to co-express one receptor subunit fused to an enzyme fragment serving as a donor, and a second dimer partner fused to an enzyme fragment serving as an acceptor. Cytoplasmic tail may have been deleted from one or both receptors. Binding of an agonist to one receptor subunit induces it to interact with its dimer partner, forcing complementation of the two enzyme fragments. This results in the formation of a functional enzyme that hydrolyzes a substrate to generate a chemiluminescent signal.

Biosimilar & Biobetter Bioassay

Ranibizumab

Anti-VEGFA mAb

Lucentis®

VEGFR2 (KDR) Dimerization

2-plate