Alternative Name
interleukin 4
Synonyms
IL4; IL-4; BCGF-1; BCGF1; BSF-1; BSF1; Il-4; Il4e12; IL2; interleukin 4; IL4; Il4
Background
Porcine IL-4 is synthesized with a 24 amino acid (aa) signal sequence.IL-4 exerts its effects through two receptor complexes (6, 7). The type I receptor, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 Rα and the common γ chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and -21). The type II receptor on nonhematopoietic cells consists of IL-4Rα and IL13Rα1.
Pathways
JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation