Novel Target Discovery Method and Strategy Design Services for NASH Therapy
The novel target discovery strategies have aroused great attention in a number of clinical settings, such as NASH therapy. To meet the challenging requirements, Creative Biolabs has built a team of experienced scientists with facilities and processes designed specifically to provide the best strategy and protocols customized to target discovery services for NASH treatment. We have successfully accomplished a number of projects and have delivered numerous novel or validated drug targets in a range of therapeutic areas.
Introduction to Target Discovery
As a significant role in drug development, target discovery has been widely used for identifying the efficacy and safety of a potential target in specific disease therapy. Recent researchers have demonstrated that a suitable target will be essential to enhance the ability of a candidate drug for a wide variety of disease treatment. A perfect target can help you understand the molecular mechanism of the disease, and evaluate the indication as well as avoiding adverse events in clinical trials. Currently, a series of proteins have been considered as the common targets, such as receptors, enzymes and various types of regulatory proteins. In addition, pilot studies have suggested that several nucleic acids can be used as targets for drug development. For instance, it has been identified that peroxisome proliferator-activator receptors (PPARs) and stearoyl-CoA desaturase (SCD) are important targets for non-alcoholic steatohepatitis (NASH) therapy. In general, there are a number of factors that should be taken into consideration for determining the targets for drug discovery. One of the most critical factors is the potential target should be able to bind to the candidate drug and induce a series of detectable biological responses.
Fig.1 Pathologic processes in NAFLD and potential therapeutic targets. (Abdul, 2017)
The Novel Target Discovery Strategies
Currently, Creative Biolabs has established a panel of platforms to identify and validate potential targets for the treatment of various liver diseases, including NASH. Equipped with a number of advanced technologies, we can provide a seamless service chain, ranging from gene expression profiling, animal modeling to target safety profiling and toxicity evaluation. Meanwhile, we are able to offer a wide array of screening assays for monitoring the interaction among cells, molecules, and pathways. As a rule, our target discovery services consist of several steps: firstly, we will identify the relationship between targets to be measured and the particular patient groups; secondly, we will determine the therapeutic value of the target in a specific patient group; thirdly, the target expression will be measured by a wide range of assays, such as high throughput screening (HIT) assay. And then the compound libraries are screened to identify the target-related compound for drug discovery. Finally, the affinity and selectivity of the target are analyzed to choose the optimal structure.
Fig.2 The Protocol of Novel Target Discovery Strategies.
Why Choose Us
With years of operational experience, Creative Biolabs is able to provide state-of-art services for any target discovery project with qualitative measurements. Our scientists specializing in NASH therapy will work with you to develop the most appropriate strategy that will offer the most meaningful data for your research. Now, we have developed efficient protocols for the identification and verification of NASH-related targets. And we can also conduct target discovery studies in various kinds of aspects, including but not limited to:
If you have any special need in our target discovery services or are interested in learning more about Creative Biolabs, please feel free to contact us for more details.
Reference
- Abdul, O.; et al. Therapies in Non-Alcoholic Steatohepatitis (Nash). Liver Int. 2017, 37(1): 97-103.
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