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Datasheets
| Specifications | |
|---|---|
| Product Description | VH 032 amine hydrochloride is a compound that binds to von Hippel-Lindau (VHL) E3 ligase and used in Protein Degraders pathway. Supplied with a primary amine functional handle at a position known not to significantly affect binding to VHL, for ready conjugation to a linker/target protein ligand. |
| Molecular Formula | C₂₂H₃₁ClN₄O₃S ∙ HCl |
| Molecular Weight (Da) | 467.02 |
| Chemical Name | (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Hydrochloride |
| Chemical Structure |  |
| Purity | 98% |
| Solubility | 40 mg/mL in DMSO |
| Size | 5 mg |
| Physical State | Lyophilized white powder |
| Storage | The powder can be stored at 4°C for 2 years or at -20°C for 3 years. Store solutions at -80°C for up to 6 months or -20°C for up to 1 month. |
| Target Information | |
|---|---|
| Target Name | Von Hippel-Lindau Tumor Suppressor |
| Alternative Names | G7; VHL; pVHL; HRCA1; HRCA1; RCA1; VHL1; Pvon Hippel-Lindau Tumor Suppressor |
| Introduction | VHL is involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It acts as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. |
| Gene ID | 7428 |
| UniProt ID | P40337 |
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