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Anti-ERBB3 MAb (Clone 4)-iFluor® 460 Succinimidyl Ester (CAT#: WJY0-LS8478)

This product is comprised of an Humanized Anti-ERBB3 IgG1-kappa antibody (Clone 4) labeled with iFluor® 460 Succinimidyl Ester. iFluor® 460 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.

  • TARGET
  • ANTIBODY
  • DYE
  • Name
  • ERBB3
  • Alternative Names
  • ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2; lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033;
  • Overview
  • This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
  • Overview
  • Humanized Anti-ERBB3 IgG1-kappa antibody (Clone 4)
  • Species Reactivity
  • Human
  • Name
  • iFluor® 460 Succinimidyl Ester
  • Color
  • Green
  • Excitation⁄Emission (nm)
  • 468/493
  • Detection method
  • Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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