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- Anti-IL22 MAb (Clone 4)-iFluor® 430 Succinimidyl Ester
Anti-IL22 MAb (Clone 4)-iFluor® 430 Succinimidyl Ester (CAT#: WJY0-LS4405)
This product is comprised of an Human Anti-IL22 IgG1-lambda (Clone 4) labeled with iFluor® 430 Succinimidyl Ester. iFluor® 430 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
- TARGET
- ANTIBODY
- DYE
- Name
- IL22
- Alternative Names
- Interleukin-22; zcyto18; IL-TIF; IL-22; IL-21; IL-D110; TIFa; ILTIF; TIFIL-23; IL-10-related T-cell-derived-inducible factor; Cytokine Zcyto18
- Overview
- Interleukin-22 (IL-22) is a cytokine important for the modulation of tissue responses during inflammation (1). Unlike the distantly related IL-10, IL-22 does not inhibit the production of proinflammatory cytokines in monocytes in response to LPS, but it has some inhibitory effects on IL-4 production from Th2 T cells. IL-22 is expressed by both the adaptive arm of the immune system such as CD4 T cell subsets including Th17 cells, as well as by innate lymphocytes such as NK and LTi-like cells (2). IL-22 is highly expressed in several chronic inflammatory conditions, and studies suggest that IL-22 plays both inflammatory and protective roles (3).
- Overview
- Human Anti-IL22 IgG1-lambda (Clone 4)
- Species Reactivity
- Human
- Name
- iFluor® 430 Succinimidyl Ester
- Color
- Green
- Excitation⁄Emission (nm)
- 433/498
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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| CAT# | Product Name | Linker | Payload |
| ADC-W-1342 | Anti-IL22 (Fezakinumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-1344 | Anti-IL22 (Fezakinumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-1341 | Anti-IL22 (Fezakinumab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| ADC-W-1343 | Anti-IL22 (Fezakinumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-1345 | Anti-IL22 (Fezakinumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
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