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- Anti-IL6 MAb (Clone 9)-iFluor® 555 Succinimidyl Ester
Anti-IL6 MAb (Clone 9)-iFluor® 555 Succinimidyl Ester (CAT#: WJY0-LS16729)
This product is comprised of an Chimeric Humanized Anti-IL6 IgG1-kappa (Clone 9) labeled with iFluor® 555 Succinimidyl Ester. iFluor® 555 Succinimidyl Ester is a Yellow-fluorescent dye and it's excitation/emission is 403/427 nm.
- TARGET
- ANTIBODY
- DYE
- Name
- IL6
- Alternative Names
- IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6
- Overview
- Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory muscle factor. In humans, it is encoded by the IL6 gene.
In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Many vascular smooth muscle cells also produce IL-6 as a proinflammatory cytokine. The role of IL-6 as an anti-inflammatory actin is mediated by its inhibitory effect on TNF-α and IL-1 and the activation of IL-1ra and IL-10.
Early evidence suggests that in the context of a broader coronavirus pandemic, IL-6 can be used as an inflammatory marker of severe COVID-19 infection with a poor prognosis.
- Overview
- Chimeric Humanized Anti-IL6 IgG1-kappa (Clone 9)
- Species Reactivity
- Human
- Name
- iFluor® 555 Succinimidyl Ester
- Color
- Yellow
- Excitation⁄Emission (nm)
- 557/570
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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| CAT# | Product Name | Linker | Payload |
| ADC-W-2249 | Anti-IL6 (Enlimomab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-2248 | Anti-IL6 (Enlimomab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-1433 | Anti-IL6-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-2251 | Anti-IL6 (Enlimomab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-1440 | Anti-IL6 (Elsilimomab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
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