Duocarmycin SA (CAT#: ADC-P-043)

ADCs Toxins, Duocarmycins, which were first isolated from Streptomyces bacteria in 1988, have shown activity in a variety of multi-drug resistant (MDR) models. Agents that are part of this class of duocarmycins have the potency in the low picomolar range. This makes them suitable for maximizing the cell-killing potency of antibody-drug conjugates to which they are attached.

Product Information

CAS NO
130288-24-3

Description
ADCs Toxins, Duocarmycins, which were first isolated from Streptomyces bacteria in 1988, have shown activity in a variety of multi-drug resistant (MDR) models. Agents that are part of this class of duocarmycins have the potency in the low picomolar range. This makes them suitable for maximizing the cell-killing potency of antibody-drug conjugates to which they are attached.

Classification
DNA Inhibitors

Molecular Weight
477.471

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

Highly recommend

Duocarmycin SA has proven to be highly effective in my cell-based assays, showing potent cytotoxicity with minimal off-target effects. The compound's stability and consistency make it a reliable option for my ongoing cancer research.

Excellent

The Duocarmycin SA from Creative Biolabs has delivered excellent results in our lab. It was easy to handle and showed strong activity in our drug screening experiments. The purity and formulation were consistent, making it a go-to compound for our studies.

Excellent

Duocarmycin SA has consistently delivered strong anti-tumor activity across multiple cancer cell lines in my tests. Creative Biolabs' product quality is top-notch, and the compound's effectiveness exceeded expectations. It's an excellent tool for cytotoxicity assays.

Excellent

I've used Duocarmycin SA in several tumor cell studies, and the results were remarkable. The compound provided by Creative Biolabs was potent and stable, yielding reproducible data with high selectivity.

Excellent

After using Duocarmycin SA in my in vitro assays, I noticed significant apoptosis in the targeted cancer cells. Creative Biolabs supplied it with great precision and reliability.

Q: 1: What is Duocarmycin SA and how does it function?
A: Duocarmycin SA is a potent cytotoxic agent used in the development of ADCs. This compound belongs to the class of duocarmycins, which are derived from natural products known for their ability to bind to the minor groove of DNA and cause cell death by alkylating the N3 position of adenine. This mechanism of action disrupts the DNA architecture, which inhibits DNA replication and ultimately leads to cell apoptosis.
Q: 2: What are the main advantages of using Duocarmycin SA in cancer research?
A: Duocarmycin SA offers high cytotoxic potency, making it suitable for enhancing the effectiveness of ADCs in treating multi-drug resistant cancers. Its low picomolar activity ensures targeted and efficient cancer cell elimination.
Q: 3: Why choose Creative Biolabs' Duocarmycin SA for ADC research?
A: Creative Biolabs offers high-quality Duocarmycin SA with consistent activity and reliability. It is an excellent choice for researchers developing potent, targeted therapies aimed at treating multi-drug resistant cancers.
Q: 4: What types of cancer are targeted using Duocarmycin SA in ADCs?
A: Duocarmycin SA is effective in targeting a wide range of cancers, particularly those with multi-drug resistance. Its ability to disrupt DNA makes it suitable for aggressive and resistant cancer types.
Q: 5: Why is Duocarmycin SA chosen for antibody-drug conjugates?
A: Duocarmycin SA is selected for inclusion in ADCs because of its potent cytotoxicity even at low doses and its ability to remain stable until reaching the target cells. Its high potency makes it effective in treating cancers with minimal off-target effects.

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