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Anti-Dabigatran (Idarucizumab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-2411)

This ADC product is comprised of an anti-Dabigatran Fab' fragment conjugated via a MC-Vc linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • Dabigatran
  • Alternative Names
  • Dabigatran
  • Overview
  • Dabigatran, sold under the brand name Pradaxa among others, is an anticoagulant medication which can be taken by mouth. It is used as an alternative to warfarin, since it does not have to be monitored by blood tests, but offers similar results in terms of efficacy.
  • Overview
  • Humanized Anti-Dabigatran IgG1-Fab’ fragment, Idarucizumab
  • Generic name
  • Idarucizumab
  • Name
  • MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Name
  • MMAE
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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