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MC-Val-Cit-PAB-PNP

MC-Val-Cit-PAB-PNP (CAT#: ADC-L-008)

ADCs linker, Mc-Val-Cit-PAB-PNP is a cathepsin cleavable linker for antibody-drug-conjugation (ADC).

Product Information

CAS NO
159857-81-5

Description
ADCs linker, Mc-Val-Cit-PAB-PNP is a cathepsin cleavable linker for antibody-drug-conjugation (ADC).

Molecular Weight
737.77

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform

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Customer Reviews FAQ

Excellent

Creative Biolabs' MC-Val-Cit-PAB-PNP was highly effective in our drug conjugation research. It enabled us to achieve precise linker-toxin conjugation, significantly advancing our ADC development studies.

Excellent

We used MC-Val-Cit-PAB-PNP from Creative Biolabs in our targeted therapy research, and it performed excellently. The cleavable linker allowed for controlled drug release in our cancer cell assays.

Excellent

Creative Biolabs' MC-Val-Cit-PAB-PNP was a key reagent in our research on controlled drug delivery systems. The product worked seamlessly in facilitating efficient payload release at the desired location.

Excellent

The use of MC-Val-Cit-PAB-PNP by Creative Biolabs in our lab allowed us to optimize the delivery of our drug conjugates, ensuring precise release and maximizing the therapeutic impact on tumor cells.

Excellent

MC-Val-Cit-PAB-PNP from Creative Biolabs enabled smooth conjugation in our targeted drug delivery studies. The linker showed excellent performance in facilitating the release of active compounds in specific conditions.

Q: 1: What is MC-Val-Cit-PAB-PNP, and what is it used for?
A: MC-Val-Cit-PAB-PNP is a cleavable linker used in antibody-drug conjugates (ADCs), enabling controlled release of cytotoxic drugs in the tumor microenvironment after internalization.
Q: 2: How does MC-Val-Cit-PAB-PNP function in ADC development?
A: This linker is cleaved by cathepsins in the lysosome, releasing the active drug within cancer cells while maintaining stability in circulation, thus enhancing ADC efficacy.
Q: 3: What types of drugs can be conjugated with MC-Val-Cit-PAB-PNP?
A: MC-Val-Cit-PAB-PNP can conjugate various cytotoxic drugs, particularly those requiring controlled release within the tumor environment, such as tubulin inhibitors or DNA-damaging agents.
Q: 4: What cancers are typically targeted using MC-Val-Cit-PAB-PNP-based ADCs?
A: MC-Val-Cit-PAB-PNP-based ADCs are commonly used in hematological malignancies and solid tumors, where lysosomal enzymes can efficiently cleave the linker for targeted drug release.
Q: 5: Does Creative Biolabs offer custom services using MC-Val-Cit-PAB-PNP?
A: Yes, Creative Biolabs provides custom ADC development services using MC-Val-Cit-PAB-PNP, offering tailored solutions for specific therapeutic targets in cancer research.

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