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Mc-vc-PAB-SN38 (CAT#: ADC-S-023)

Linker-Toxin SET, this set is made by SN38 conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11)and it stabilizes the complex between topo-I and DNA which collide with moving DNA replication forks, eventually leading to double stranded DNA damage.

  • Product Information
  • Description
  • Linker-Toxin SET, this set is made by SN38 conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11)and it stabilizes the complex between topo-I and DNA which collide with moving DNA replication forks, eventually leading to double stranded DNA damage.
  • Molecular Weight
  • 991.07
  • Purity
  • 95%

For Research Use Only. NOT FOR CLINICAL USE.

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