Microcystin LR (CAT#: ADC-P-112)

ADCs Toxins, Microcystin LR is a cyclic heptapeptide produced by the species of cyanobacteria Microcystis. Microcystin exhibits cytotoxic, carcinogenic and pro-oxidateive properties.

Product Information

CAS NO
169789-55-3

Description
ADCs Toxins, Microcystin LR is a cyclic heptapeptide produced by the species of cyanobacteria Microcystis. Microcystin exhibits cytotoxic, carcinogenic and pro-oxidateive properties.

Classification
Others

Molecular Weight
1009.3

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Excellent

Creative Biolabs' Microcystin LR worked flawlessly in our protein phosphatase inhibition assays. Its high purity and reliability ensured accurate data, greatly improving the efficiency of our lab work.

Excellent

We used Microcystin LR from Creative Biolabs for testing in zebrafish models. The product's quality was exceptional, yielding reproducible and clear results in our toxicity assessments.

Excellent

Creative Biolabs' Microcystin LR proved to be invaluable for our enzyme inhibition experiments. The results were consistent across multiple trials, making it a reliable reagent in our laboratory.

Excellent

We incorporated Creative Biolabs' Microcystin LR in our liver cell toxicity tests. The product was easy to work with, and its quality ensured precise measurements of toxin impact on cell viability.

Excellent

The Microcystin LR from Creative Biolabs was a key component in our apoptosis studies. Its high potency and consistency allowed us to generate accurate data across different biological systems.

Q: 1: What is Microcystin LR and its primary source?
A: Microcystin-LR is a potent hepatotoxin produced by certain cyanobacteria, commonly found in freshwater environments. Its primary source includes species like Microcystis, Anabaena, and Oscillatoria.
Q: 2: How does Microcystin LR exhibit cytotoxic effects?
A: Microcystin LR inhibits protein phosphatases 1 and 2A, leading to hyperphosphorylation of proteins. This disruption of cellular processes causes cell toxicity and is a subject of study in cancer and environmental toxicology.
Q: 3: What are the typical applications of Microcystin LR in research?
A: Microcystin LR is used in various research areas, including toxicology, cancer research, and environmental science. Its cytotoxic and carcinogenic properties make it valuable for studying cellular responses and oxidative stress mechanisms.
Q: 4: What concentrations of Microcystin LR are typically used in cell-based assays?
A: The concentration of Microcystin LR used in cell-based assays depends on the specific cell type and study. It generally ranges from nanomolar to micromolar levels, depending on the sensitivity of the cells to the toxin.
Q: 5: What analytical methods are commonly used to detect Microcystin LR?
A: Liquid chromatography coupled with mass spectrometry (LC-MS) and enzyme-linked immunosorbent assays (ELISA) are commonly used methods for detecting and quantifying Microcystin LR in various biological and environmental samples.
Q: 6: How is Microcystin LR used in drug development or therapeutic research?
A: Microcystin LR is used in drug development research as a tool for investigating protein phosphatase inhibition, cell signaling, and oxidative stress. It provides insights into pathways relevant to cancer and other diseases influenced by dysregulated protein phosphorylation.

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