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Pironetin (CAT#: ADC-P-125)
ADCs Toxins, Pironetin is a potent inhibitor of tubulin. Pironetin covalently binds tubulin. Systematic alanine scanning shows, that the pironetin binding site was determined to be Lys352 of alpha-tubulin. Lys352 is located at the entrance of a small pocket of alpha-tubulin, and this pocket faces the beta-tubulin of the next dimer. This is the first compound that covalently binds to the alpha subunit of tubulin and Lys352 of alpha-tubulin and inhibits the interaction of tubulin heterodimers. HCT-116: IC50=0,002 uM; PSN1 : IC50=0,003 uM; T98G : IC50=15,43 uM; A549 : IC50=0,002 uM (preliminary laboratory results). Journal of Antibiotics (1996), 49, 173-180.
- Product Information
- CAS NO
- 151519-02-7
- Description
- ADCs Toxins, Pironetin is a potent inhibitor of tubulin. Pironetin covalently binds tubulin. Systematic alanine scanning shows, that the pironetin binding site was determined to be Lys352 of alpha-tubulin. Lys352 is located at the entrance of a small pocket of alpha-tubulin, and this pocket faces the beta-tubulin of the next dimer. This is the first compound that covalently binds to the alpha subunit of tubulin and Lys352 of alpha-tubulin and inhibits the interaction of tubulin heterodimers. HCT-116: IC50=0,002 uM; PSN1 : IC50=0,003 uM; T98G : IC50=15,43 uM; A549 : IC50=0,002 uM (preliminary laboratory results). Journal of Antibiotics (1996), 49, 173-180.
- Classification
- Microtubule Inhibitors
- Molecular Weight
- 324.45
- Purity
- 95%
For Research Use Only. NOT FOR CLINICAL USE.
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Customer Reviews
FAQ
Excellent
Creative Biolabs' Pironetin has been a powerful tool in our ADC research. Its potent inhibition of tubulin, specifically binding to Lys352, led to excellent cytotoxicity results across multiple cancer cell lines.
Excellent
Using Pironetin from Creative Biolabs delivered remarkable outcomes in our studies. The covalent binding to alpha-tubulin at Lys352 provided targeted and potent inhibition, significantly improving our results in ADC-based cancer research.
Excellent
Pironetin has proven to be an outstanding tubulin inhibitor in our lab. The high specificity and strong cytotoxicity across cancer lines made it a valuable component in our drug conjugate studies. Highly recommend Creative Biolabs' Pironetin.
Excellent
Pironetin by Creative Biolabs proved highly effective in our lab's cancer research. The covalent interaction with alpha-tubulin significantly disrupted tubulin dynamics, leading to strong anti-cancer effects in our cell line tests.
Excellent
We've seen great results with Pironetin from Creative Biolabs. Its unique tubulin-binding mechanism at Lys352 provided exceptional control in disrupting cancer cell proliferation, making it a valuable addition to our ongoing research.
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