Podophyllotoxin (CAT#: ADC-P-126)

ADCs Toxins, Potent Inhibitor of microtubule assembly an DNA topoisomerase II

Product Information

CAS NO
518-28-5

Description
ADCs Toxins, Potent Inhibitor of microtubule assembly an DNA topoisomerase II

Classification
Microtubule Inhibitors

Molecular Weight
414.41

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

Published Data

+ Submit Publications

Submit a review or a question

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

Reviews

Literature

Protocol

Customer Reviews and FAQs

There are currently no Customer reviews or questions for ADC-P-126. Click the button above to contact us or submit your feedback about this product.

Customer Reviews FAQ

Excellent

The Podophyllotoxin from Creative Biolabs exceeded our expectations. It provided excellent performance in our cell cycle inhibition assays, contributing to significant advancements in our research.

Excellent

In our drug screening project, Creative Biolabs' Podophyllotoxin proved to be a reliable compound. The consistency in its effects across multiple trials was outstanding and greatly improved our workflow.

Excellent

Podophyllotoxin from Creative Biolabs worked excellently in our anti-tumor studies. Its superior quality and high activity level made it a valuable addition to our compound library.

Excellent

We used Podophyllotoxin from Creative Biolabs in our apoptosis experiments. The product's high quality ensured accurate data and made it an essential reagent in our lab.

Excellent

We incorporated Podophyllotoxin from Creative Biolabs in our cytotoxicity assays. The product's stability and effectiveness helped us obtain reproducible results, making it a key component in our research.

Q: 1: What is the mechanism of action of Podophyllotoxin?
A: Podophyllotoxin acts by inhibiting microtubule assembly, effectively preventing cell division and inducing apoptosis, making it a potent agent against cancer and viral infections.
Q: 2: What types of cancers can Podophyllotoxin be used to treat?
A: Podophyllotoxin is most effective against cancers such as lung, testicular, and lymphomas. It is also used in the development of derivatives for broader therapeutic applications.
Q: 3: What is the difference between Podophyllotoxin and its derivatives?
A: Podophyllotoxin derivatives, such as etoposide and teniposide, have been chemically modified to enhance solubility and reduce toxicity while retaining their cytotoxic effects.
Q: 4: What are the known side effects of Podophyllotoxin in preclinical studies?
A: Podophyllotoxin has shown potential side effects such as myelosuppression, gastrointestinal issues, and neurotoxicity in preclinical studies, requiring careful dosage optimization.
Q: 5: Why was Podophyllotoxin chosen as the toxin in the ADC?
A: Podophyllotoxin was chosen as the toxin in ADCs due to its strong cytotoxic properties, particularly its ability to disrupt microtubule formation. This disruption prevents cell division, effectively inducing apoptosis in rapidly dividing cancer cells. Its well-established anti-tumor activity, combined with the potential to be selectively delivered to cancer cells through an ADC, makes it an appealing choice. Furthermore, podophyllotoxin's efficacy in overcoming drug resistance in certain cancers enhances its suitability for use in targeted therapies.

Quick Links

ADC Toxins

Drug-linker Complexes

Customized ADCs

Anti-Ab ADCs

Online Inquiry

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.