CD70

CD70, also known as CD27L, CD27-L, CD27LG, TNFSF7, or TNLG8A, is a cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is a type II transmembrane protein containing 193 amino acids with a molecular weight of ~50 kDa. CD70 is a ligand for TNFRSF27 (CD27) and the interaction between CD70 and CD27 is crucial for T-cell activation, costimulated T-cells proliferation, and cytolytic T-cell generation. CD70 is also reported to participate in B-cell activation.

CD70 is essentially absent in normal non-lymphoid tissues while its constitutive expression is observed in many hematological malignancies and solid tumors. High level CD70 expression has been documented in lymphomas, renal cell carcinoma (RCC), nasopharyngeal carcinoma, and Epstein-Barr virus-induced carcinomas while the expression level of CD27, its receptor, also showed positive correlation to that of CD70 in some cases. CD70 has become an active target for immunotherapy development. Current therapies against CD70-bearing cancer cells include antibody-induced ADCC, ADC, and antibody-mediated CD70 blockage.

Entrez Gene ID: 970
UniProt ID: P32970