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TGFB2

Transforming growth factor-beta 2 (TGFB2) is an extracellular glycosylated protein that has multiple cellular functions and plays an important role during embryonic development. It is also known as glioblastoma-derived T-cell suppressor factor, G-TSF and BSC-1 cell growth inhibitor. The crystal structure of the TGF-beta 2 monomer lacks a well-defined hydrophobic core and displays an unusual elongated non-globular fold. Eight cysteine residues form four intra-chain disulfide bonds, creating the characteristic knotted arrangement. The dimer is stabilized by a ninth cysteine, which forms an inter-chain disulfide bond, and by two identical hydrophobic interfaces.
TGFB1 and TGFB2 have been found in porcine platelets. In both bovine bone and porcine platelets, TGFB2 is less abundant than TGFB1, constituting only approximately 18% of the total recovered TGFB. Moreover, TGFB2 has the remarkable sequence conservation with TGFB1. A number of studies reveal that TGFB2 is involved in apoptotic pathways in Synovial Fibroblasts and PAK Pathway. TGFB2 is reported to be associated with several diseases which include Holt-Oram Syndrome, an autosomal dominant disorder that affects bones in the arms and hands (the upper limbs) and may also cause heart problems.
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Entrez Gene ID: 7042
UniProt ID: P61812