Tolytoxin (CAT#: ADC-P-142)

ADCs Toxins, Tolytoxin is a macrolactone with the following biological effects: cytotoxin, actin disruptor. IC50: 0.5-8 nM

Product Information

Description
ADCs Toxins, Tolytoxin is a macrolactone with the following biological effects: cytotoxin, actin disruptor. IC50: 0.5-8 nM

Classification
Others

Molecular Weight
850.09

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform

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Customer Reviews FAQ

Excellent

I used Tolytoxin in my research on cytoskeletal dynamics, and its potent actin disruption effects were invaluable in studying cancer cell migration and metastasis.

Excellent

Tolytoxin from Creative Biolabs has proven highly effective in my cytotoxicity assays. Its ability to disrupt actin filaments provided critical insights into cell morphology changes in cancer cells.

Excellent

Tolytoxin demonstrated strong cytotoxic effects in my cell viability studies. Its impact on cellular structures made it a great tool for understanding cell death mechanisms in cancer research.

Excellent

In my ADC studies, Tolytoxin served as a powerful payload, significantly enhancing the cytotoxicity of the conjugates. The actin disruption resulted in efficient tumor cell targeting and destruction.

Excellent

Tolytoxin has been a valuable compound in my ADC research. Its potent cytotoxicity and actin-disrupting abilities allowed for highly effective tumor cell eradication when conjugated to antibodies.

Q: 1: How does Tolytoxin work in ADCs?
A: Tolytoxin binds to actin filaments, disrupting cytoskeletal function in cancer cells. When conjugated to antibodies, it selectively kills target cells upon internalization.
Q: 2: What cancers can Tolytoxin-based ADCs target?
A: Tolytoxin-based ADCs can target various cancers, particularly those with high cytoskeletal activity, such as breast cancer, melanoma, and other solid tumors.
Q: 3: What are the key challenges of using Tolytoxin in ADCs?
A: Challenges include ensuring controlled drug release, minimizing off-target effects, and optimizing linker stability for efficient delivery of Tolytoxin to cancer cells.
Q: 4: What analytical methods confirm Tolytoxin conjugation in ADCs?
A: Techniques such as HPLC, mass spectrometry, and SDS-PAGE are used to confirm the successful conjugation of Tolytoxin to antibodies, ensuring its proper attachment and functionality.
Q: 5: Does Creative Biolabs provide custom ADC development using Tolytoxin?
A: Yes, Creative Biolabs offers custom ADC development services using Tolytoxin, enabling researchers to create highly potent, targeted therapies for specific cancer types.

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