Glycan in Dermatology

Glycans are sugars that have a variety of functions in the body. Glycans are located on the cell surface and interact with proteins including bacteria, bacterial toxins, antibodies, and tumor antigens as a form of cellular communication. It is important to investigate the glycans in dermatology related diseases and glycans also play an important role in the structure and biology of healthy skin. Creative Biolabs is pleased to share our cutting-edge technology and extensive expertise in anti-glycans to facilitate our clients’ research and project development. We can offer high-quality customized services by adjusting protocols to meet even the most specific requirements.

Dermatology

Dermatology is the branch of medicine associated with the skin, nails, hair and their diseases. It is a specialty with both medical and surgical fields. A dermatologist serves as a doctor to treat a wide range of diseases such as some cosmetic problems of the skin, scalp, hair, and nails. The dermatology involves many aspects, including cosmetic dermatology, dermatopathology, immunodermatology, mohs surgery, pediatric dermatology, teledermatology, and dermatoepidemiology.

Fig.1 Glycoconjugates that formed by carbohydrates are covalently bonded to proteins and lipids on mammalian cell membranes.^{1, 2}

The Role of Glycans in Dermatology

Glycans possess different functions in the body. There are two distinct functions of glycans in dermatology. One function is involved in structural and modulatory activities, while the second function is specific recognition of glycan structures by other molecules, such as receptor proteins or lectins. Once sugars recognize proteins, glycation occurs, which prematurely ages the body by decreasing the flexibility of proteins, causing cataracts as well as decreased nerve and renal functioning and myocardial contractility. The process of glycation is disadvantageous to the body, but glycans function positively on the cell surface to act as antennae, allowing efficient communication. Sugars are essential to human life, and their decrease with aging renders an attractive target for aging prevention. Glycans on the cell surface can be linked to fluorescent substances and analyzed for changes in their distribution following cosmeceutical application, which provides a way of investigating topical glycan modulation and improving the appearance of aged skin.

A common feature of atopic dermatitis and contact dermatitis is the entry of leukocytes into the dermis, where they can recruit other types of cells that mediate tissue damage. Sometimes this process leads to the chronic expression of E-selectin on endothelial cells. E-selectin can recruit circulating lymphocytes carrying the cutaneous lymphocyte antigen, which tends to be a specific E-selectin ligand epitope carried on a subset of P-selectin glycoprotein ligand-1 (PSGL-1) molecules. Some T helper 1 (Th1) lymphocytes can enter the skin via expression of the PSGL-1 ligand for P-selectin. These results were derived from model systems and suggest potential selectin-based therapeutic targets for future development.

Features of Our Antibody

• High stability
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Studies on the function of mammalian glycosylation show that glycans are involved in multiple disciplines spanning ontogeny, immunology, neurobiology, hematology, and metabolism and are related to some genetic diseases. Thus, the development of antibodies against all kinds of glycans is a useful tool for the diagnosis and treatment of these diseases. Now Creative Biolabs provides comprehensive anti-glycan antibody discovery and development services for customers all over the world. Our high-quality and high specificity antibodies will promote your project to success, please contact us for more information.

References:

1. Li, Yuqing, et al. "The importance of glycans of viral and host proteins in enveloped virus infection." Frontiers in Immunology 12 (2021): 638573.
2. Distributed under Open Access license CC BY 4.0, without modification.