Research-Grade Recombinant Protein Vaccine Discovery Service for Infectious Disease Research
With the continuous mutation of pathogens and the emergence of new infectious diseases, traditional vaccine development methods face various challenges. Recombinant protein technology, with its unique advantages, has become one of the core technologies for the development of new vaccines. Creative Biolabs, combining years of research experience in the biopharmaceutical field, provides professional recombinant protein vaccine discovery services to support the research and control of infectious diseases.
Introduction to Recombinant Protein Vaccines
Recombinant protein vaccines are vaccines developed using genetic recombination technology. They work by introducing specific protein genes of pathogens into host cells, utilizing the biosynthetic mechanisms of these cells to produce the target proteins. These proteins play a key role in vaccines, stimulating the body's immune response to provide protection against specific pathogens.
Recombinant Protein Vaccines Have Multiple Advantages over Traditional Vaccines
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Rapid Development: The development of recombinant protein vaccines is fast, enabling rapid response to emerging infectious disease threats.
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Mature Technology: This technology is mature and has a reliable research and development foundation.
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High Safety: As they do not contain live pathogens, recombinant protein vaccines reduce infection risks and increase safety.
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Large-Scale Production: Capable of large-scale production, meeting emergency and widespread vaccination needs.
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Strong Immune Response: Effectively induce strong immune responses, providing effective protection.
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Precise Design: Can be finely designed according to the characteristics of pathogens, enhancing vaccine potency and tolerance.
Research-Grade Recombinant Protein Vaccine Discovery Service Process
1. Requirement Analysis: In-depth communication with clients to understand their research goals and specific needs.
2. Gene Cloning: Extracting the DNA sequence of relevant genes from the target pathogen, then using recombinant DNA technology to insert these genes into host cells.
3. Protein Expression and Purification: Expressing the target protein in host cells, followed by a series of separation and purification steps to extract pure recombinant protein.
4. Vaccine Design and Optimization: Combining pathogen characteristics and immune response experiments to design and optimize recombinant protein vaccines.
Service Advantages
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Efficient Recombinant Protein Design: Utilizing advanced bioinformatics tools to quickly design and optimize vaccine candidate proteins.
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Diverse Expression Systems: Providing flexible expression systems to meet the needs of different types of proteins.
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Host Cell/System
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Expression System Type
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Advantages
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Disadvantages
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Applications
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E. coli Cells
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Prokaryotic Expression System
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Clear genetic background;
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Fast cell proliferation;
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High expression level;
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Good stability;
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Strong anti-contamination ability;
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Cost-effective.
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Unable to perform complex post-translational modificationsl
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Potential endotoxin production.
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Suitable for the expression of a wide range of proteins, especially for small molecule protein production
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Yeast Cells
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Eukaryotic Expression System
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Clear and safe genetic background;
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Fast proliferation;
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High-density fermentation in cheap media;
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Capable of complex post-translational modifications;
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Strong secretion expression capability;
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Effectively reducing downstream purification costs.
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Glycosylation patterns not completely identical to human proteins;
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May affect protein function and immunogenicity.
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Widely used in industrial production, suitable for complex protein expression
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Chinese Hamster Ovary (CHO) Cells
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Eukaryotic Expression System
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Capable of post-translational modifications very similar to humans;
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Suitable for producing various complex large-molecule proteins;
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Mature industrial production technology.
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Higher cultivation costs;
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Complex cell culture process;
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Longer production cycle.
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Suitable for producing various types of proteins, especially those requiring complex post-translational modifications
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Baculovirus-Insect Expression System
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Eukaryotic Expression System
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Utilizes baculovirus to infect insect cells;
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Allows large-scale production;
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Enhances protein solubility and post-translational modifications;
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Produces high expression levels of secreted proteins.
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Strict cultivation conditions;
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Relatively high cost;
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Post-translational modifications may differ from human systems.
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Suitable for the production of high-expression and complex proteins
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Strict Quality Control: Employing a strict quality management system to ensure high purity and activity of vaccine candidate proteins.
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Customized Client Services: Providing customized research plans and comprehensive technical support according to client-specific needs.
Creative Biolabs consists of experienced experts and researchers, ensuring that each service provided meets the expectations and requirements of clients. For more detailed information about our research-grade recombinant protein vaccine discovery services or to discuss your project needs, please feel free to contact us.
For Research Use Only. We do not provide direct services or products for patients.
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