Research-Grade Viral Vector Vaccine Discovery Service for Infectious Disease Research

In the field of infectious disease research, viral vector vaccines, as an innovative immunization strategy, have become an important part of modern medical research. Creative Biolabs provides professional and comprehensive research-level viral vector vaccine discovery services to scientific research institutions and pharmaceutical companies worldwide, committed to promoting new progress in infectious disease vaccine R&D.

What is a Viral Vector Vaccine?

A viral vector vaccine is a vaccine that uses a modified virus (as a vector) to deliver key genetic information (such as the S protein gene) of a specific pathogen (like the novel coronavirus). This vaccine strategy aims to stimulate the human immune response, enabling the immune system to recognize and fight against the actual pathogen. The vector virus is usually harmless to humans, like adenovirus, and modified so that it cannot cause disease.

Fig.1 Approaches for influenza vaccine development.^1,2

Viral vector vaccines can be further subdivided into two categories:

Advantages of Viral Vector Vaccines

• Effective Induction of Cellular Immune Response: Viral vector vaccines are particularly effective in stimulating cellular immune responses, which is crucial for the prevention and treatment of many diseases, such as viral infections.
• Rapid Immune Response Generation: As viral vector vaccines mimic the natural infection process of pathogens, they can quickly stimulate the immune system to produce a protective immune response.
• Multidimensional Immune Response Construction: They can construct one or more cytokine genes simultaneously to enhance the immune response or change its direction.
• Adaptability: Viral vector vaccines can be custom-designed for different pathogens, suitable for the vaccine development of various infectious diseases.
• Long-term Immune Memory: Especially non-replicating viral vector vaccines, which can produce long-term immune memory in the body.
• Safety: Since the vector viruses have been modified to be harmless, these vaccines have higher safety, especially the non-replicating vector vaccines.

Research-Grade Viral Vector Vaccine Development Services at Creative Biolabs

1. Needs Analysis and Project Planning: Develop experimental plans based on client needs.

2. Identify key antigens for vaccine development, then choose a suitable viral vector (such as adenovirus) for genetic modification.

3. Validate the vaccine construction's effectiveness through experiments.

4. Cell and animal experimental validation:

• Cell testing: Test the vaccine's activity and immunogenicity under cell culture conditions.
• Animal model testing: Assess the vaccine's immunogenic effects and safety through animal experiments.

5. Immune Response Analysis:

• Cellular and Humoral Immunity Assessment: Evaluate the vaccine-induced immune response using methods like Enzyme Linked Immunospot Assay, Intracellular Cytokine Staining (ICS), ELISA, etc.
• Immune Memory and Persistence Assessment: Evaluate the vaccine's persistence and memory B-cell response through long-term animal experiments.

6. Data Analysis and Report Delivery.

7. Follow-up Services and Support.

For more information about Creative Biolabs' research-grade viral vector vaccine discovery services, please contact us. We look forward to collaborating with you.

References:

1. Kerstetter, LJ.; et al. Adenoviral vectors as vaccines for emerging avian influenza viruses. Frontiers in Immunology. 2020, 11:607333.
2. under Open Access license CC BY 4.0, without modification.

• DNA Vaccine Discovery
• mRNA Vaccine Discovery
• Polypeptide Vaccine Discovery
• Recombinant Protein Vaccine Discovery