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Ad Fiber Knob & EPCAM Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem Diabody) Human Ad Fiber Knob EPCAM Inquiry
SCIGG-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scIgG) Human Single chain IgGs Ad Fiber Knob EPCAM Inquiry
FVTIG-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv4-Ig) Human Appended IgGs Ad Fiber Knob EPCAM Inquiry
BSSG-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv-IgG) Human Appended IgGs Ad Fiber Knob EPCAM Inquiry
IGLFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs Ad Fiber Knob EPCAM Inquiry
BSGV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-Fv) Human IgG-Fv Ad Fiber Knob EPCAM Inquiry
BSDG-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fv-IgG) Human Appended IgGs Ad Fiber Knob EPCAM Inquiry
BABFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins Ad Fiber Knob EPCAM Inquiry
FABVC-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins Ad Fiber Knob EPCAM Inquiry
SCDBC-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob EPCAM Inquiry
BSDBC-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob EPCAM Inquiry
SCDBF-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob EPCAM Inquiry
BSFVF-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob EPCAM Inquiry
BSDBF-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments Ad Fiber Knob EPCAM Inquiry
BSTF-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv Ad Fiber Knob EPCAM Inquiry
BSCFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv-Fc) Human scFv-Fc Ad Fiber Knob EPCAM Inquiry
MNAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Miniantibody) Human Miniantibody Ad Fiber Knob EPCAM Inquiry
BSFC-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv-CH3) Human scFv-CH3 Ad Fiber Knob EPCAM Inquiry
BSCC-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL Ad Fiber Knob EPCAM Inquiry
BIBD-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob EPCAM Inquiry
FABFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob EPCAM Inquiry
MiniB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob EPCAM Inquiry
SCDB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob EPCAM Inquiry
FABIG-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob EPCAM Inquiry
TRIB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob EPCAM Inquiry
BSIG-004 Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob EPCAM Inquiry
CROSSAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob EPCAM Inquiry
IGFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob EPCAM Inquiry
BSDB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob EPCAM Inquiry
BSFAB-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob EPCAM Inquiry
BSFV-004 Recombinant Anti-Ad Fiber Knob x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob EPCAM Inquiry
BIBD-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (Bibody) Human Bibody CD3 EPCAM Inquiry
BIBD-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (Bibody) Human Bibody CD28 EPCAM Inquiry
BIBD-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Bibody) Human Bibody CD3 EPCAM Inquiry
BIBD-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Bibody) Human Bibody CD28 EPCAM Inquiry
BIBD-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob ITGAV Inquiry
BIBD-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob CEA Inquiry
BIBD-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Bibody) Human Bibody Ad Fiber Knob CD40 Inquiry
FABFV-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 EPCAM Inquiry
FABFV-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 EPCAM Inquiry
FABFV-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 EPCAM Inquiry
FABFV-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-Fv) Human Fab-Fv CD28 EPCAM Inquiry
FABFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob ITGAV Inquiry
FABFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob CEA Inquiry
FABFV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fab-Fv) Human Fab-Fv Ad Fiber Knob CD40 Inquiry
MiniB-H255 Recombinant Human Anti-CD3 x Human Anti-EPCAM Bispecific Antibody (Minibody) Human Minibody CD3 EPCAM Inquiry
MiniB-H235 Recombinant Human Anti-CD28 x Human Anti-EPCAM Bispecific Antibody (Minibody) Human Minibody CD28 EPCAM Inquiry
MiniB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Minibody) Human Minibody CD3 EPCAM Inquiry
MiniB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Minibody) Human Minibody CD28 EPCAM Inquiry
MiniB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob ITGAV Inquiry
MiniB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob CEA Inquiry
MiniB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Minibody) Human Minibody Ad Fiber Knob CD40 Inquiry
SCTB-H150 Recombinant Human Anti-EPCAM x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 EPCAM Inquiry
SCTB-H130 Recombinant Human Anti-EPCAM x Human Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 EPCAM Inquiry
SCDB-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 EPCAM Inquiry
SCDB-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 EPCAM Inquiry
FABIG-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 EPCAM Inquiry
FABIG-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 EPCAM Inquiry
TRIB-H255 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Triple Body) Human Triple Body CD3 EPCAM Inquiry
TRIB-H235 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Triple Body) Human Triple Body CD28 EPCAM Inquiry
BSIG-H253 Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 EPCAM Inquiry
BSIG-H233 Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 EPCAM Inquiry
CROSSAB-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD3 EPCAM Inquiry
CROSSAB-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD28 EPCAM Inquiry
IGFV-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 EPCAM Inquiry
IGFV-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 EPCAM Inquiry
BSDB-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD3 EPCAM Inquiry
BSDB-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD28 EPCAM Inquiry
BSFAB-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 EPCAM Inquiry
BSFAB-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 EPCAM Inquiry
BSFV-H253 Recombinant Human Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 EPCAM Inquiry
BSFV-H233 Recombinant Human Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 EPCAM Inquiry
SCTB-052 Recombinant Anti-EPCAM x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 EPCAM Inquiry
SCTB-031 Recombinant Anti-EPCAM x Anti-CD28 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD28 EPCAM Inquiry
SCDB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 EPCAM Inquiry
SCDB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD28 EPCAM Inquiry
SCDB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob ITGAV Inquiry
SCDB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob CEA Inquiry
SCDB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Ad Fiber Knob CD40 Inquiry
FABIG-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 EPCAM Inquiry
FABIG-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Fab-IgG) Human Fab-IgG CD28 EPCAM Inquiry
FABIG-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob ITGAV Inquiry
FABIG-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob CEA Inquiry
FABIG-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Fab-IgG) Human Fab-IgG Ad Fiber Knob CD40 Inquiry
TRIB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Triple Body) Human Triple Body CD3 EPCAM Inquiry
TRIB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Triple Body) Human Triple Body CD28 EPCAM Inquiry
TRIB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob ITGAV Inquiry
TRIB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob CEA Inquiry
TRIB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Triple Body) Human Triple Body Ad Fiber Knob CD40 Inquiry
BSIG-079 Anti-CD3 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 EPCAM Inquiry
BSIG-059 Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-IgG) Human IgG-IgG CD28 EPCAM Inquiry
BSIG-005 Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob ITGAV Inquiry
BSIG-003 Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob CEA Inquiry
BSIG-002 Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (IgG-IgG) Human IgG-IgG Ad Fiber Knob CD40 Inquiry
CROSSAB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD3 EPCAM Inquiry
CROSSAB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (CrossMab) Human CrossMab CD28 EPCAM Inquiry
CROSSAB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob ITGAV Inquiry
CROSSAB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob CEA Inquiry
CROSSAB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (CrossMab) Human CrossMab Ad Fiber Knob CD40 Inquiry
IGFV-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 EPCAM Inquiry
IGFV-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (IgG-scFv) Human IgG-scFv CD28 EPCAM Inquiry
IGFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob ITGAV Inquiry
IGFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob CEA Inquiry
IGFV-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (IgG-scFv) Human IgG-scFv Ad Fiber Knob CD40 Inquiry
BSDB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD3 EPCAM Inquiry
BSDB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Diabody) Human Diabody CD28 EPCAM Inquiry
BSDB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob ITGAV Inquiry
BSDB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob CEA Inquiry
BSDB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Diabody) Human Diabody Ad Fiber Knob CD40 Inquiry
BSFAB-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 EPCAM Inquiry
BSFAB-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem Fab) Human Tandem Fab CD28 EPCAM Inquiry
BSFAB-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob ITGAV Inquiry
BSFAB-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob CEA Inquiry
BSFAB-002 Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Tandem Fab) Human Tandem Fab Ad Fiber Knob CD40 Inquiry
BSFV-079 Recombinant Anti-CD3 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 EPCAM Inquiry
BSFV-059 Recombinant Anti-CD28 x Anti-EPCAM Bispecific Antibody (Tandem scFv) Human Tandem scFv CD28 EPCAM Inquiry
BSFV-005 Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob ITGAV Inquiry
BSFV-003 Recombinant Anti-Ad Fiber Knob x Anti-CEA Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob CEA Inquiry
BSFV-002 Recombinant Human Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Tandem scFv) Human Tandem scFv Ad Fiber Knob CD40 Inquiry

Background

The Ad fiber knob refers to the fiber protein found in adenoviruses, which is responsible for viral attachment and entry into host cells. EPCAM, or epithelial cell adhesion molecule, is a protein expressed on the surface of various types of epithelial cells and is often overexpressed on tumor cells. The anti-Ad fiber knob×anti-EPCAM bispecific antibody can be constructed as a therapeutic agent that combines two different antibody fragments to target specific molecules on the surface of cells. This dual binding allows for the targeted delivery of adenoviral vectors directly to tumor cells, while also preventing adenoviral infection by blocking the interaction of the viral fiber knob with its receptor. This BsAb has potential applications in the field of cancer gene therapy. By selectively delivering therapeutic agents to cancer cells, it may enhance treatment efficacy and minimize off-target effects.

Fig.1 Functional mechanisms of Ad fiber knob and EPCAM. (Krasnykh, et al., 2000; Schnell, et al., 2013) Fig.1 Functions of Ad fiber knob and EPCAM.1,2

References

  1. Krasnykh, Victor, et al. "Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity." Cancer Research 60.24 (2000): 6784-6787.
  2. Schnell, Ulrike, et al. "EpCAM: structure and function in health and disease." Biochimica et Biophysica Acta (BBA)-Biomembranes 1828.8 (2013): 1989-2001.
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