Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Single-chain Diabody) (SCDB-005)

Recombinant Anti-Ad fiber knob x Anti-ITGAV Bispecific Antibody (Single-chain Diabody) is designed to be expressed as one polypeptide chain with four variable domains from two parental antibodies. The middle linker is long enough to form scFv dimers between the two diabody chains. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.

Datasheet INQUIRY

Specifications

Targets

Ad Fiber Knob & ITGAV

Type

Single-chain Diabody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Colorectal cancer (CRC); Prostate cancer; Ovarian cancer

Targets

Target 1

Ad Fiber Knob

Alternative Names

Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber

Target 2

ITGAV

Gene ID

3685

UniProt ID

P06756

Alternative Names

ITGAV; integrin, alpha V; CD51; MSK8; VNRA; VTNR; integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-Ad Fiber Knob x Anti-ITGAV Bispecific Antibody (Single-chain Diabody) (CAT#: SCDB-005)

Specifications

Targets

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