As one of the most well-recognized experts, Creative Biolabs is proud to provide our clients with high-quality services related to animal model research projects to meet various demands precisely. More specifically, our scientists are specialized in inflammation model creation, model selection, and preclinical experiments and promise to assist you in every step of your research and accelerate the speed to achieve your goals.
Fig. 1 Endogenous IFN-β expression and the effect of IFN-β treatment on CAIA model mice.1
Rheumatoid arthritis (RA) is a typical, chronic autoimmune disease that primarily affects the joints, ultimately leading to synovitis that often develops into cartilage and bone erosion, apart from which, extra-articular features are presented, including subcutaneous nodules, vasculitis, and pulmonary fibrosis, particularly in severer cases. Collagen antibody-induced arthritis (CAIA), as a widely used model of arthritis induced by systemic administration of mixtures of CII-specific monoclonal antibodies that target various epitopes of type II collagen, is the direct derivative of CIA. Conventionally, a cocktail of arthritogenic monoclonal antibodies directed against type II collagen (CII) combined with a boost of LPS is used to induce arthritis in CAIA model. Practically, this model is useful for studying the pathological role of individual gene products, pro-inflammatory and anti-inflammatory cytokines, screening and evaluating anti-inflammatory agents. Creative Biolabs offers preclinical assessment services, including but not limited to:
As is seen in CIA, CAIA model displays similar clinical and histologic characteristics and simultaneously involves important features of human RA, such as inflammatory synovitis, formation of pannus (an aggressive fibrovascular tissue that invades the joint), cartilage destruction, and bone resorption, although acute components (e.g. infiltration with neutrophils) prevail when compared to CIA.
One particular advantage of CAIA over CIA is that the model is amenable for use in strains or genotypes not genetically susceptible for CIA. Moreover, CAIA, in contrast to CIA, is a rapid model (onset within 48h plus peak disease within 8 days) with high uptake rate, synchronicity and lack of influence of Freund's adjuvant, which was used for CIA model and affects the immune system. CAIA requires formation of immune complexes on the cartilage and complement activation while its induction of arthritis is B cell and T cell independent.
Meanwhile, in order to meet our customers' specific requirements and their various research objectives, Creative Biolabs also offers other rodent inflammatory & immunological disease models listed as follows that you may be interested in:
Creative Biolabs is a good partner for designing, validating and analyzing animal efficacy studies due to our expertise and years of experience. Contact us to get our integrated in vivo pharmacology solutions for your next project and beyond.
Reference
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