Creative Biolabs has spent decades of efforts to optimize and bring specialized non-human primate (NHP) neurological models to our global customers. We have unparalleled platforms and rich experience to guarantee cost-effective service. We warmly welcome our customers to consult and negotiate their cutting-edge projects with us.
Generally speaking, the nervous system consists of the brain, spinal cord, and nerves. The whole body's responses and functions are controlled by the nervous system. Disorder or dysfunction within any part of the nervous system may lead to difficulties in swallowing, breathing, speaking, moving, learning, etc.
Neurological disease can be described as any disorder within the nervous system. It consists of a series of symptoms caused by structural, biochemical, or electrical abnormalities in the brain, spinal cord, or other nerves. The characterized symptoms include partial or complete paralysis, muscle weakness, partial or complete loss of sensation, seizures, poor cognitive abilities, unexplained pain, etc.
Non-human primates (NHPs) are widely used for studying human brain function and neurological diseases. For example, research on NHPs has made a great contribution to our knowledge of Alzheimer's disease. Due to the previous studies, effective proposed treatments have been developed. Such models also play vital importance in developing dopamine agonists and deep brain stimulation which have proved to be available treatments for Parkinson's disease. Different forms of affective disorders including Tourette syndrome, major depression, and anxiety disorders are now being treated using deep-brain stimulation based on the pioneered work on NHPs.
| Neurological Disease Model | |
| Parkinson's Disease (PD) Model | Parkinson's disease (PD) is a debilitating neurodegenerative disease characterized by shaking, rigidity, slow movement, and walking difficulty. Our team provides two widely used PD models: 6-OHDA and MPTP-induced PD models. Three major testing items are provided to assist the research including general measures, behavioral tests, and functional imaging. |
| Middle Cerebral Artery Occlusion (MCAO) Model | Middle cerebral artery occlusion (MCAO) is a standard animal model of focal cerebral ischemia. Occlusion of the middle cerebral artery results in some defects: sensory loss of the contralateral face and arm, contralateral neglect syndrome, aphasia, paralysis or weakness of the contralateral face and arm, etc. We build MCAO models using microneurosurgery technique. Follow-up tests include physiological parameters, a standard neurological deficit score, and MRI imaging. |
| Spinal Cord Injury (SCI) Model | A spinal cord injury (SCI) is damage to the spinal cord that alters its function temporarily or permanently. SCI models can be classified into 6 categories including compression, contusion, distraction, transaction, dislocation, and chemical models. Creative Biolabs is capable of providing different kinds of SCI based on clients' needs. Furthermore, we can provide multiple assessments including motor-evoked potential (MEP), somatosensory-evoked potential (SSEP), MR imaging, and monkey hindlimb score (MHS), etc. |
| Cerebral Infarction Model | A cerebral infarction is a necrotic area in the brain caused by a narrowing or blockage of the arteries that supply blood and oxygen to the brain. We build cerebral infarction models based on the advanced microneurosurgery technique. Endpoint measurements include physiological parameters, a standard neurological deficit score, and MRI imaging. |
| Cerebral Stroke Model | A stroke is cell death caused by the poor blood supply to the brain. It will result in part of the brain not functioning properly. Microneurosurgery technique is adopted to build cerebral stroke models. A full set of tests will be provided including physiological parameters, a standard neurological deficit score, and MRI imaging. |
| Primate Epilepsy Model | Epilepsy is a chronic disease caused by the sudden abnormal discharge of brain neurons, leading to transient brain dysfunction. NHP models of epilepsy can assist us in understanding the pathophysiology and developing the potential epilepsy therapy in humans. we have rich experience in constructing experimental epilepsy models (including generalized and focal epilepsy models) in rhesus and macaque monkeys. |
| Primate Alzheimer's Disease (AD) Model | Alzheimer's disease is a progressive neurodegenerative disease with insidious onset. Clinically, it is characterized by general dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visual-spatial skills, executive dysfunction, and personality/behavior changes. Primate models of AD can better present many clinical symptoms such as memory impairment, cognitive impairment, and complicated social communication, which makes them ideal preclinical tools in AD research. |
| Primate Peripheral Nerve Injury (PNI) Model | The commonly used PNI models are the facial nerve model, the sciatic nerve model, and the femoral nerve model. Creative Biolabs has developed and validated the PNI model in primates. These models exhibit the following clinical manifestations: movement disorders, sensory disorders, reflex disorders, and autonomic dysfunction. |
| Primate Vascular Dementia (VaD) Model | VaD is the general term for dementia caused by cerebrovascular damage. It refers to severe cognitive dysfunction syndrome, including the impairment of memory, cognition, and behavior. Creative Biolabs has successfully established the NHP models of VaD. Besides, we will provide the following related analysis services: cerebral blood flow measurements, MRI imaging, histopathological examination, behavioral experiments, learning and memory assessment, electrophysiological recordings, WB validation, etc. |
| Primate Depression and Anxiety Model | Depression, also known as depressive disorder, is the main type of mood disorder with significant and lasting depression as its main clinical feature. Anxiety, also called anxiety neurosis, is the most common type of neurosis. NHP models of depression and anxiety are recognized as powerful preclinical tools by more and more researchers. Creative Biolabs has successfully established the depression model and anxiety model in NHPs. |
Creative Biolabs provides alternative neurological disease models for worldwide clients. Novel/unique disease models can also be established upon specific custom requests. Our scientists are glad to leverage their extensive expertise in NHP Disease Models to benefit worldwide clients. Please feel free to contact us for further discussions.
For Research Use Only.
