With accumulated years of CRO services experience, Creative Biolabs acts as a trustworthy partner of our global clients and has owned their approval. We provide non-human primate (NHP) disease models for multiple indications, including but not limited to Parkinson's Disease (PD) Model, Middle Cerebral Artery Occlusion (MCAO) Model, and Spinal Cord Injury (SCI) Model. With advanced and fully-equipped facilities, a team of experienced scientists, and the most stringent Q&C system, we offer preclinical non-GLP drug development services and have assisted our valuable clients in their project implementation on our pharmacology and pharmacodynamics (PD/PK) platform.
The functional recovery of human peripheral nerves after the repair is not satisfactory. Researchers have proposed a variety of possible reasons for poor functional recovery. However, the dominant factors underlying the functional recovery process are still uncovered, thus leading to the challenge of functional recovery improvement through current clinical treatments. Research on functional recovery after nerve injury relies on reliable animal models. However, the current PNI animal models have some defects. Therefore, the success of this research in the future depends to a large extent on the improvement of PNI animal models.
Currently, the commonly used PNI models are the facial nerve model, the sciatic nerve model, and the femoral nerve model. The facial nerve axotomy model is the typical model for studying motoneurons. The sciatic nerve is a "mixed" nerve, which contains motor axons and sensory axons. Therefore, damage to the sciatic nerve, such as the main branch of the tibial nerve or the sciatic nerve of the small muscle branch such as the soleus, can cause damage to both motor and sensory axons. Similar to the sciatic nerve, the femoral nerve is also a mixed nerve. The damage to the femoral nerve can impair not only the motor nerve innervation for multiple muscles but also sensory nerve innervation for muscles and skin.
It is well-known that the NHPs have advantages over rodents in translational medicine research. This consensus makes them become the ideal preclinical experimental animal species in drug development studies. Therefore, Creative Biolabs has developed and validated the PNI model in primates. These models exhibit the following clinical manifestations: movement disorders, sensory disorders, reflex disorders, and autonomic dysfunction. In addition to modeling service, we will provide the following related analysis services: neuropathological analysis, morphological and morphometric evaluation of nerves, immunohistochemistry, cytokine analysis, growth factor analysis, neurotrophin secretion detection, clinical evaluation of nerve paralysis, electrophysiological evaluation, histopathological evaluation, etc. to learn more about the pathogenesis of the PNI and the efficacy of your therapeutic candidates.
If you are interested in the NHP models of PNI, please feel free to contact us for further discussions. The professional R&D team of Creative Biolabs is willing to provide you with scientific solutions for your study project and is honored to assist you in your study design and project management. We will work closely with you to achieve your study goal.
Creative Biolabs offers various Neurological Disease Models you may be interested in.
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