shRNA Adenovirus Serotype 5 (ΔE1/E3), pU6-(DOLK-shRNA-Seq1)(CAT#: AdV-SI0466WQ)

This product is a DOLK-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The protein encoded by DOLK gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man. The expression of DOLK-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.

Specifications
Family Adenoviridae
Species Adenovirus
Serotype HAdV-5
Backbone AdV-5 (ΔE1/E3)
Tropism Both nondividing and dividing cells
Insert DOLK-shRNA-Seq1
Related Target/Protein DOLK
Region CDS
TargetSeq GCCTTTGCTTGGACTAGTCAT
NCBI RefSeq NM_014908
Alternative Names DK; DK1; CDG1M; SEC59; TMEM15
Titer >1*10^10 GC/mL
Related Diseases Dolichol kinase deficiency
Target Gene
Gene ID 22845
Uniprot ID Q9UPQ8

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