shRNA Lentivirus (self-inactivating), pH1-(FAM49B-shRNA-Seq1)(CAT#: LV-SI0676WQ)
This product is a FAM49B-shRNA encoding Lentivirus, which is based on HIV-1 serotype. FAM49B is a regulator of mitochondrial function and integrity and also inhibits T-cell activation by repressing RAC1 activity and modulating cytoskeleton reorganization. The expression of FAM49B-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Retroviridae |
Species | Lentivirus |
Serotype | HIV-1 |
Backbone | Lenti-SIN |
Tropism | Both nondividing and dividing cells |
Insert | FAM49B-shRNA-Seq1 |
Related Target/Protein | FAM49B |
Region | CDS |
TargetSeq | GTCATTCTGCTTGAGGGTAAT |
NCBI RefSeq | NM_016623 |
Alternative Names | L1; BM-009 |
Titer | >1*10^10 GC/mL |
Related Diseases | Pancreatic ductal adenocarcinoma (PDAC) |