shRNA Lentivirus (self-inactivating), pU6-(COQ9-shRNA-Seq1)(CAT#: LV-SI0119WQ)

This product is a COQ9-shRNA encoding Lentivirus, which is based on HIV-1 serotype. The COQ9 gene encoded protein is likely necessary for biosynthesis of coenzyme Q10, as mutations at this locus have been associated with autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency. The expression of COQ9-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.

Specifications
Family Retroviridae
Species Lentivirus
Serotype HIV-1
Backbone Lenti-SIN
Tropism Both nondividing and dividing cells
Insert COQ9-shRNA-Seq1
Related Target/Protein COQ9
Region CDS
TargetSeq CAGTGGAAACCAGACTGAGAA
NCBI RefSeq NM_020312
Alternative Names COQ10D5; C16orf49; HSPC326; PSEC0129
Titer >1*10^10 GC/mL
Related Diseases Autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency
Target Gene
Gene ID 57017
Uniprot ID O75208

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