To expedite the development of antibody drugs, Creative Biolabs offers a wide range of services in the design, construction, and validation of animal models. With our diverse and efficient experimental antibody-directed enzyme prodrug therapy (ADEPT) analysis platforms, we assist you in minimizing risks and accelerating the path to market during the ADEPT development process. Nowadays, we can create suitable animal models based on patient demographics, tumor types, and specific ADEPT project objectives.

Introduction

During the ADEPT development, the design, construction, and validation of animal models play a crucial role. At Creative Biolabs, our animal models assist clients in validating the biological principles of ADEPT therapies and provide insights into the interactions between antibodies and drugs. Moreover, through these animal studies, our team can conduct preliminary safety assessments, identifying potential toxicity and side effects. In addition, our ADEPT animal models can also efficiently simulate diverse tumor pathological features, allowing for a full evaluation of ADEPT's efficacy while offering valuable feedback for further optimization of the therapy. Besides, we offer a variety of animal experiment services to help clients determine the ideal drug dosage and administration protocols, ultimately enhancing treatment outcomes.

Fig.1 Animal Modeling Process .^1,3

ADEPT Animal Model Platform

• ADEPT Animal Model Design:
  - Requirements Analysis: Conduct an initial project evaluation based on the client's specific needs to identify the drug targets, mechanisms of action, and expected outcomes.
  - Model Selection: Offer a variety of animal model options including mice, rats, and non-human primates, tailored to different disease models such as cancer and autoimmune disorders.
• ADEPT Animal Model Development:
  - Transgenic Animal Generation: Utilize gene recombination technologies to create transgenic animals that express specific targets, simulating human disease conditions.
  - Establishment of Transplant Models: For instance, develop xenograft models by implanting human tumor cells to assess the targeting efficacy of antibody drugs.
  - Optimization of Drug Administration Routes: Determine the most suitable routes of administration (such as intravenous or intraperitoneal injection) based on the drug characteristics, and make necessary adjustments in dosage and timing.
• ADEPT Animal Model Validation:
  - Validation of Biological Characteristics: Assess whether the constructed animal models meet expected biological characteristics and disease progression through physiological metrics and pathological analyses.
  - Evaluation of Drug Efficacy: Use the established animal models to evaluate the therapeutic effects of antibody drugs, including tumor growth inhibition and assessment of immune responses.

Services

In the rapidly advancing field of biomedicine, ADEPT has garnered significant attention due to its precise targeting and remarkable efficacy. As your trusted partner in biotechnology, Creative Biolabs is excited to announce that we now offer a comprehensive range of customized services related to ADEPT therapies, designed to elevate your research and development projects to new heights.

1. Animal Models Development

Establishing the right animal model is crucial for success in scientific research. At Creative Biolabs, we focus on developing tumor xenograft mouse models that accurately mimic the human tumor environment. These models effectively replicate the biological characteristics of tumors, providing a more authentic experimental foundation for your ADEPT therapies. Whether you are investigating specific cancer types or particular drug applications, our research team will tailor the most suitable animal models to ensure your results are both predictable and credible.

2. In Vivo Distribution, Metabolism, and Bioactivity Testing

We understand that the in vivo behavior of a drug is vital to its efficacy. Creative Biolabs offers a series of testing services for drug distribution, metabolism, and bioactivity, enabling you to accurately assess the performance of ADEPT therapies in vivo. Our state-of-the-art technology platform and expert team will employ various techniques to precisely measure drug distribution across different tissues and analyze the formation of its metabolites, helping to clarify the mechanisms of action and biosafety of the drug.

3. ADEPT Efficacy and Safety Evaluation

Creative Biolabs is dedicated to providing comprehensive assessment services to streamline your research process. Through a series of rigorous experimental designs, we will thoroughly evaluate the effectiveness of antibody-directed enzyme prodrug therapy, exploring potential side effects and safety risks. Our data will serve as strong support for your future clinical strategy development.

Fig.2 Characteristics of Monkey Model Study Groups.^2,3

Advantages

• Expert Support for Animal Modeling Techniques
• Accelerated ADEPT Development Timeline
• Cost Reduction Strategies
• Compliance and Quality Assurance
• Diverse Experimental Services
• Access to Extensive Animal Resources and Facilities
• Data Analysis and Report Preparation

Creative Biolabs offers high-quality animal model services tailored to your ADEPT research. Our research team can customize precise animal models based on your specific requirements, ensuring the reliability and effectiveness of your study results. We understand that a successful ADEPT study relies on a solid experimental foundation. By choosing our animal model services, you can significantly enhance your research and contribute to the advancement of antibody-drug targeting therapies. Please feel free to contact us anytime for more information.

References

1. Zou, Yuchen, et al. "Effects of maternal high-fructose diet on long non-coding RNAs and anxiety-like behaviors in offspring." International Journal of Molecular Sciences 24.5 (2023): 4460.
2. Palmer, Clovis S., et al. "Non-human primate model of long-COVID identifies immune associates of hyperglycemia." Nature Communications 15.1 (2024): 6664.
3. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only | Not For Clinical Use