Next-IO™ Anti-LAG-3 Therapeutic Monoclonal Antibody Program

About This Program

This program aims to develop anti-LAG-3 therapeutic monoclonal antibody for colorectal cancer immunotherapy.

Rationale for our program:

Given the above, LAG3 is a promising immune checkpoint for clinical translation.

LAG-3

LAG-3 is a type I transmembrane protein of the immunoglobulin (Ig) superfamily. It is usually expressed in activated T cells, natural killer cells or B cells, and functionally negatively regulate the homeostasis of these cells. LAG-3 has been identified as a next generation of immunological checkpoint proteins that play a variety of roles in cancer immunity, including:

LAG-3 signaling and interaction with other immune checkpoints. Fig.1 LAG-3 signaling and interaction with other immune checkpoints. (Long, 2018)

Supporting Data

The data support the rationale for the development of the first-in-class human anti-LAG-3 with an improved therapeutic index for the treatment of CRC.

Colorectal Cancer

Ongoing Clinical Trials

Program Management

We have extensive knowledge of end-to-end program development. For each program, we are committed to delivering the final complete program to our clients within 1.5 years before entering the IND stage.

Next-IO™ Anti-LAG-3 Therapeutic Monoclonal Antibody Program

Cooperation

Creative Biolabs is looking for potential partners (include but not limit to major pharma or biotech firms) to develop LAG-3 therapeutic monoclonal antibody program together. Our scientists are dedicated to bringing years of valuable experience to our partner and achieve a meaningful partnership together. For any partners interested in our Next-IO™ programs, Creative Biolabs welcomes collaboration.

Here are two ways for your choice, and please contact us for more details.

1) Collaborate with us and co-develop the programs from the discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate for our programs.

With our quality control protocol and knowledge of global regulatory requirements, we can help our partners further their programs with more chances to succeed. Look forward to cooperating with you in the near future.

References

For Research Use Only | Not For Clinical Use

Online Inquiry
Copyright © 2024 Creative Biolabs. All Rights Reserved.
ISO 9001 Certified - Creative Biolabs Quality Management System.