Antigen-presenting cells (APCs) play a crucial role in activating and modulating the immune response by presenting antigens to T cells. Artificial APCs (aAPCs) are synthetic or engineered structures designed to mimic the functions of natural antigen-presenting cells (APCs), such as dendritic cells. aAPCs can be designed to express specific co-stimulatory molecules necessary for the activation and differentiation of T cells. The aAPC system has several advantages over traditional APC cells, including controllable co-stimulation signals, versatility, cost-effective production, enhanced T-cell activation, reduced complexity and safety concerns, tailored antigen presentations, and potential therapeutic applications. At Creative Biolabs, we provide APC development services tailored to the client's needs.

The Design of APCs

• Types of APCs

The aAPCs include various types of cells or particles that are engineered to present antigens to T cells. For example, aAPCs are typically created by modifying cell lines or primary cells to express specific antigen-presenting molecules, such as MHC class I or II molecules, co-stimulatory molecules, and cytokines. The synthetic particles including liposomes, biodegradable polymers, and magnetic beads can be loaded with antigenic peptides, co-stimulatory molecules, and other immune-modulating signals. They can be easily manipulated and deliver antigens to immune cells effectively.

The specific types of aAPCs can vary depending on the intended application and research purpose. At Creative Biolabs, our scientists are committed to developing customized APCs to meet various research needs. Our R & D team has rich experience and provides professional suggestions and support for your projects.

Table. 1 Types of APC

Fig.1 The history and types of APCs.¹

• The Co-stimulatory Molecules of APCs

The co-stimulatory molecules and cytokines play a vital role in the activation and expansion of T cells. For instance, co-stimulatory molecules such as CD40L, CD70, and 4-1BBL can enhance T cell activation and proliferation, while cytokines like IL-2 and IL-15 promote T cell survival and differentiation. At Creative Biolabs, our experts design the aAPCs that express or load a combination of these molecules to optimize the T-cell response.

Fig.2 The signals of APCs.²

Next-Generation APC Development Services

Creative Biolabs is dedicated to the development of customized APCs, robustly supporting researchers in advancing immunology research. Depending on the specific requirements of our clients, we utilize state-of-the-art engineering technologies to modify cells or synthesize particles to meet their needs. Our team, equipped with extensive expertise, offers professional consultations and technical support to facilitate the success of your research project. Contact us today to discuss your research needs and discover how our innovative APC solutions can benefit your project.

Advantages

• Diversity: We offer various types of APCs and the most appropriate solution for clients.
• Customization: We offer tailored APC development services to meet your specific requirements.
• Advanced Technology: Our experts utilize cutting-edge technologies and innovative methods to develop highly efficient and specific APCs.

References

1. Neal, Lillian R., et al. "The basics of artificial antigen-presenting cells in T cell-based cancer immunotherapies." Journal of immunology research and therapy 2.1 (2017): 68.
2. Perica, Karlo, Alyssa K. Kosmides, and Jonathan P. Schneck. "Linking form to function: Biophysical aspects of artificial antigen presenting cell design." Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1853.4 (2015): 781-790.

For Research Use Only | Not For Clinical Use