Knockdown Cell Line Products

Knockdown Cell Lines are specially engineered cell lines designed to reduce the expression of specific genes through techniques such as RNA interference (RNAi). This powerful tool allows researchers to investigate gene function, study disease mechanisms, and explore potential therapeutic targets. By effectively silencing target genes, Knockdown Cell Lines enable detailed analysis of cellular processes and pathways, facilitating advancements in molecular biology and drug development. These custom cell lines are invaluable in both academic and pharmaceutical research settings, providing insights into gene regulation and cellular dynamics.

Advantages of Knockdown Cell Lines

Gene Function Analysis

Knockdown cell lines are used to investigate the biological role of specific genes by observing the effects of their reduced expression on cellular processes.

Disease Modeling

Knockdown cell lines are valuable for modeling diseases, particularly cancer and genetic disorders, by mimicking the loss of function of genes associated with these diseases.

Target Validation

Knockdown cell lines help in validating potential drug targets by assessing the outcome of targeting specific genes on cell viability or proliferation.

Pathway Dissection

Knockdown cell lines are used to dissect signaling pathways and understand interactions between different genes and their contributions to various cellular functions.

Therapeutic Development

Knockdown approaches can aid in developing gene therapy strategies, where the aim is to silence harmful genes associated with disease.

High-Throughput Screening

Knockdown cell lines are used in high-throughput screening to identify compounds that can restore function or counteract effects caused by the gene knockdown.

Featured Products

If you need a custom knockdown cell line product, you can contact our technicians directly for information to accelerate your scientific research!

Applications of Knockdown Cell Lines

Assessment of Biomarkers
Evaluate the role of certain genes as biomarkers for disease prognosis or treatment response by examining phenotypic changes in response to gene silencing.
Development of Novel Therapeutics
Explore new therapeutic targets, including the development of RNAi-based therapies that aim to silence disease-causing genes.
Cell Signaling Pathway Dissection
Dissect signaling pathways by targeting key regulatory genes, leading to insights into how cellular signals are transmitted and how disruptions can lead to disease.
Functional Analysis of Non-Coding RNAs
Study the potential roles of non-coding RNAs, such as long non-coding RNAs and microRNAs, in regulating gene expression and cellular behavior.
RNAi Therapeutics Research
Used in the development and testing of RNA interference-based therapies, assessing the efficiency and specificity of various RNAi molecules.
Studying Resistance Mechanisms
Investigate mechanisms of resistance to therapies by silencing genes that may contribute to escape from treatment.

Workflow of Knockdown Cell Lines

Published Data

Fig.1 Knockdown Cell Line. (Escalona, et al., 2022) Fig.1 The figure above represents the knockdown of TIMP-2 in a cell line.¹

Contact Us for More

At Creative Biolabs, we specialize in providing high-quality knockdown cell lines tailored to your research needs. Our team is equipped to offer custom services, allowing you to develop specific cell lines that meet your experimental requirements. Whether you need assistance with a particular gene knockdown or other specialized modifications, we are here to help. Don't hesitate to contact us for more information, and let us partner with you to achieve your research objectives.

Reference

Escalona, Ruth M et al. "Knock down of TIMP-2 by siRNA and CRISPR/Cas9 mediates diverse cellular reprogramming of metastasis and chemosensitivity in ovarian cancer." Cancer cell international vol. 22,1 422. Distributed under Open Access license CC BY 4.0, without modification.

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