CellOnco™ HEK293T-Tg(Human 5-HT1B Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM686)

Creative Biolabs offers HEK293T-Tg(Human 5-HT1B Receptor) Division-Arrested Cell which 5-HT1B receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human 5-HT1B Receptor) Division-Arrested Cell was engineered to express the receptor human 5-HT1B (NM_000863.1). This cell line can be used to study 5-HT1B receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

5-HT1B receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

5-HT1B

Serotonin

Human

HEK293T

Expression vector containing full-length human HTR1B cDNA (GenBank accession number NM_000863.1) with FLAG tag sequence at N-terminus

NM_000863.1

The human serotonin receptor 5-HT1B is a G protein-coupled receptor. 5-HT1B receptors are present in many parts of the central nervous system, but most notably, can be found in the basal ganglia, striatum, and frontal cortex. 5- HT1B receptors inhibit the release of many neurotransmitters, such as serotonin, GABA, acetylcholine, and glutamate. 5-HT1B ligands may prove to be therapeutic in the treatment of various disorders such as depression, anxiety, and aggression.