CellOnco™ HEK293T-Tg(Human Gαqi5//Human mGlu3 Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM617)

Creative Biolabs offers HEK293T-Tg(Human Gαqi5//Human mGlu3 Receptor) Division-Arrested Cell which mGlu3 receptor stably expressed in HEK293T cells which overexpress Gαqi5.

HEK293T-Tg(Human Gαqi5//Human mGlu3 Receptor) Division-Arrested Cell was engineered to express the receptor human mGlu3 (NM_000840) and Gαqi5 gene. This cell line can be used to study mGlu3 receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

mGlu3 receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

mGlu3

Metabotropic Glutamate

Human

HEK293T Gαqi5

Expression vector containing full-length human GRM3 cDNA (GenBank Accession Number NM_000840) with FLAG tag sequence at N-terminus

NM_000840

Metabotropic glutamate receptor mGluR3 (mGlu3) is a G protein-coupled receptor for glutamate. Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and functions to regulate excitability via pre- and postsynaptic mechanisms. The mGluR3 receptor is widely expressed in glial cells but also shows discrete localization both pre- and postsynaptic on glutamatergic and other neurotransmitter synapses. It is also expressed within forebrain regions including hippocampus and thalamus. Agonists of mGluR3 have been shown to suppress enhanced glutamatergic excitations in brain synapses known to be involved in the expression of fear/anxiety in animals and humans. It is anticipated that mGluR3 receptor represent a promising new target for treatment of anxiety and stress-related disorders in humans.