CellOnco™ HEK293T-Tg(Human GPRC5A Receptor) Stable Cell Line, Single Clone (CAT#: ITS-0624-HMM381)

Creative Biolabs offers HEK293T-Tg(Human GPRC5A Receptor) Stable Cell Line which GPRC5A receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human GPRC5A Receptor) Stable Cell Line was engineered to express the receptor human GPRC5A (NM_004313.3). GPRC5A is a versatile GPCR with widespread expression and potential roles in various physiological processes. This cell line can be used to study GPRC5A receptor function, signaling pathways, and potential therapeutic interventions.

Minimally modified GPCRs directly selected in functional assays;
Strict quality control;
Parental and orthologous cell lines are available.

GPRC5A receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

GPRC5A

Orphan

Human

HEK293T

Expression vector containing full-length human GPRC5A cDNA with FLAG tag sequence at N-terminus and ARRB2 cDNA

NM_004313.3

GPRC5A was identified and initially characterized through genomic sequencing and bioinformatics approaches aimed at cataloging GPCRs. It belongs to the Class C (metabotropic glutamate receptor-like) family of GPCRs, which are characterized by a large N-terminal extracellular domain and a long cysteine-rich domain involved in ligand binding. GPRC5A, like other Class C GPCRs, consists of an extracellular N-terminal domain, seven transmembrane helices connected by intra- and extracellular loops, and an intracellular C-terminal domain. The N-terminal domain of GPRC5A is notable for its cysteine-rich region, which is involved in ligand binding and receptor activation. GPRC5A is widely expressed in various tissues throughout the body, with higher expression levels observed in the brain, lung, kidney, and liver. Its expression pattern suggests potential roles in diverse physiological processes, including sensory perception, cellular signaling, and metabolic regulation.