CellOnco™ HEK293T-Tg(Human MC1 Receptor) Division-Arrested Cell, Single Clone (CAT#: ITS-0624-HMM614)

Creative Biolabs offers HEK293T-Tg(Human MC1 Receptor) Division-Arrested Cell which MC1 receptor stably expressed in HEK293T cells.

HEK293T-Tg(Human MC1 Receptor) Division-Arrested Cell was engineered to express the receptor human MC1 (NM_002386.3). This cell line can be used to study MC1 receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.

Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.

MC1 receptor function, signaling pathways, and potential therapeutic interventions.

GPCR

MC1

Melanocortin

Human

HEK293T

Full-length Human MC1R cDNA (GenBank Accession Number NM_002386.3) with FLAG-tag sequence at the N-terminus

NM_002386.3

The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR) or melanotropin receptor, is a seven transmembrane G-protein coupled receptor expressed on the surface of melanocytes MC1 receptors binds to a class of pituitary peptide hormones known as melanocortins. Binding of melanocortins to five subtypes of melanocortin receptors exert a large array of central and peripheral effects. MC1R is one of the key proteins expressed in skin and hair and hair color. Activation of MC1R by agonist stimulates the synthesis of eumelanin by a process melanogenesis, primarily activating adenylate cyclase. MC1R has a potential role in anti-inflammatory and melanoma treatment. Further studies of the MC1 receptor are essential in gaining a better understanding of the mechanism and in vivo regulation of pigmentation and anti-inflammatory functions.