Short Decsription
Creative Biolabs offers HEK293T-Tg(Human PTH2 Receptor) Division-Arrested Cell which PTH2 receptor stably expressed in HEK293T cells.
Description
HEK293T-Tg(Human PTH2 Receptor) Division-Arrested Cell was engineered to express the receptor human PTH2 (NM_005048). This cell line can be used to study PTH2 receptor function, signaling pathways, and potential therapeutic interventions. Dividing-arrest cells are cells that are normally kept under specific culture conditions or treated with agents that prevent cell division from being held in a non-dividing state. This can be achieved through methods such as serum starvation, chemical inhibitors of cell cycle progression, or genetic modification.
Features
Well-characterized stable cell lines;
for cell-based high-throughput screening;
Low-cost evaluation of stable cell lines or limited quantities of compounds.
Applications
PTH2 receptor function, signaling pathways, and potential therapeutic interventions.
Protein Target
GPCR
Receptor Name
PTH2
Receptor Family
Parathyroid Hormone
Species
Human
Parental Cell Line
HEK293T
Transfection
Expression vector containing full-length human PTH2 cDNA (GenBank Accession Number NM_005048) with FLAG tag sequence at N-terminus
Gene
NM_005048
Background
The parathyroid hormone (PTH) receptor type 2 (PTHR2) is a receptor for PTH and tuberoinfundibular peptide TIP39. Unlike the PTH1 receptor, the PTH2 receptor has extreme low affinity for PTH-related peptide PTHrP. PTH2 receptor expression is high in the CNS, where it is concentrated in limbic, hypothalamic, and sensory areas, especially hypothalamic periventricular neurons, nerve terminals in the median eminence, superficial layers of the spinal cord dorsal horn, and the caudal part of the sensory trigeminal nucleus. Peripheral expression in pancreatic islet somatostatin cells is most dramatic. PTHR2 may be functionally involved in pituitary and pancreatic hormone release and pain perception.

For Research Use Only | Not For Clinical Use

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