To meet the challenging requirements, Creative Biolabs has equipped a team of experienced scientists with facilities and processes designed specifically to provide the best strategy and protocols customized to contrast-enhanced MRI tumor imaging services. We have accomplished some projects and have delivered numerous novel or validated tumor contrast imaging solutions for our worldwide customers.

Introduction to Contrast-Enhanced MRI Technology

Over the past few decades, a large number of MRI contrast agents have demonstrated the potential for highly sensitive, more targeted imaging and improved patient management in tumor diagnostic imaging. Recently, contrast-enhanced-MRI (CE-MRI) has been considered an important diagnostic imaging tool for tumor oncology research. CE-MRI can enhance the imaging of tumor lesion location, classification, and grade to help guide biopsy, clinical treatment, and patient monitoring and management. At the same time, information on lesion location, classification, and grading is provided to help guide biopsy, treatment planning, and monitoring treatment response.

As a result, Creative Biolabs provides a panel of CE-MRI services that utilize novel contrast agents, higher field intensity Settings, and clearer time-resolved imaging to improve the spatial and temporal resolution and quality of conventional images, further increasing the sensitivity of detection of smaller metastatic lesions. For instance, based on the principle of increased tumor blood vessel distribution, our functional MRI platforms, such as perfusion imaging services, are gradually being used for brain tumor imaging. Among them, the rCBV threshold, all passage time, peak enhancement time, and other parameters on CE-MRI play a decisive role.

Fig.1 Contrast-Enhanced MRI Imaging in Glioblastoma.¹

In addition, we have also established a CE-MRA detection platform, which mainly performs vascular anatomic imaging detection for samples of patients with peripheral artery occlusion or aneurysm disease and various less common diseases. Our CE-MRA real-time imaging technology offers specific advantages such as speed, high accuracy, y, and sensitivity. Moreover, we can accelerate MRA data acquisition by several orders of magnitude by upgrading compressed sensing technology combined with dynamic iterative Bayesian algorithms.

Chef Services

Our unique platform imaging technology enables the analysis of multiple tumor sample types through the h quantitative acquisition of detection signals and has become a powerful quantitative diagnostic tool.

Fig.2 Workflow of Multi-Parametric MRI Radiomics for Predicting Ki-67 Expression in Rectal Cancer.²

• Targeted Imaging Molecular Biomarker Discovery

In our labs, tumor-specific molecular biomarkers have been broadly used for assisting in vivo MRI imaging diagnostic analysis. a wide variety of receptor-targeted imaging probes, such as peptide, antibody, and nanoparticle-based probes, have been designed to improve the specificity of cancer cells.

• Monitoring Response to Therapy

Currently, contrast-enhanced MRI technologies have become valuable indicators for predicting and monitoring therapeutic responses in cancer patients. A series of DCE and perfusion parameter data derived from our CE-MRI projects have considerable potential benefits for patient management, enabling timely changes in treatment and saving unnecessary treatment costs.

• Tumor Prognosis Prediction

Creative Biolabs enables the comprehensive assessment of multiple key prognostic factors in different tumor models. For example, the expression level of a range of tumor-associated antigen proteins, such as Ki-67, can be analyzed by our non-invasive imaging biomarkers to provide additional prognostic and personalized management value.

Why Creative Biolabs?

As a well-established company in the bio-industry, we offer quality CE-MRI analysis and solutions. Guaranteed to perform within the specified time frame, and the data quality is always maintained to the end. Other features:

• Multiple MRI contrast agents
• Professional knowledge of cancer imaging technology
• Integrated solution based on many target biomarkers
• An efficient and cost-effective process

With years of operational experience, Creative Biolabs can provide state-of-the-art services for any MRI-based project with qualitative measurements. Our scientists specialized in tumor imaging will work with you to develop the most appropriate strategy that will offer the most meaningful data for your research. If you have any special needs in our viral vector services or are interested in learning more about our company, please feel free to contact us or directly send us an inquiry.

References

1. Paech, D., et al. Nuclear overhauled enhancement imaging of glioblastoma at 7 Tesla: region-specific correlation with apparent diffusion coefficient and histology. PLoS One. 2015, 10(3): e0121220.
2. Yao, X., et al. A novel radiomics based on multi-parametric magnetic resonance imaging for predicting Ki-67 expression in rectal cancer: a multicenter study. BMC Medical Imaging. 2023, 23(1): 168.

For Research Use Only | Not For Clinical Use