AGS is one of the most common cell lines for the xenograft modeling of gastric cancer. It can provide an opportunity to understand the pattern of tumor growth as well as to evaluate new gastric cancer therapies in in vivo studies. Creative Biolabs offers state-of-the-art services for engineering the gastric cancer cell BGC-823 for self-destruction that meet your specific tumor research needs. Besides, we also offer immune reactivity assessment services and toxicity assessment services after engineering.

Gastric Cancer Cell BGC-823

Gastric cancer is the fourth most common malignant tumor in the world. It is usually diagnosed in the late stages. Different stages have different therapy methods. Combinational chemotherapy, radiotherapy, and surgery are general treatments for gastric cancer patients.

Previous research shows that the more appropriate disease models lead to the development of better therapeutic approaches. Animal models are the most practical tools in cancer research. Tumor xenograft models established in immunodeficient mice are good cancer models for oncological studies and there is agreement that the use of these models for the development of anti-cancer drugs in the preclinical phase is beneficial.

Several models of gastric carcinoma xenografts using different cell lines have been developed. AGS is one of the most common cell lines for the xenograft modeling of gastric cancer. It can provide an opportunity to understand the pattern of tumor growth as well as to evaluate new gastric cancer therapies in in vivo studies.

Fig.1 Immunofluorescence images of AGS cells. (Eftang, et al., 2012)

Engineering Gastric Cancer Cell AGS for Self-destruction

Creative Biolabs provides the complete set of service which exploit and manipulate AGS cell line to promote anti-gastric cancer immunity. The self-destruction means the strategy which transfects overexpressed-cytokines into cancer cells by different technologies, thereby achieving the purpose of engineering AGS cells. This method does not directly stimulate the AGS cell line, thereby avoiding the risk of increasing AGS cells-dependent metastases. Besides, Creative Biolabs also offers Immune Reactivity Assessment services and Toxicity Assessment services after engineering.

Fig.2 The workflow of engineering gastric cancer cell AGS for self-destruction. (Creative Biolabs)

Our Services

Expert in cell therapy and cancer immunity, Creative Biolabs provides the comprehensive self-destruction services to help you complete your research. You can find the exact strategies and assays in following units:

More gastric cancer cell lines for self-destruction, please visit the unit of Engineering Cancer Cells for Self-destruction.

With the team of scientists come from different research backgrounds, Creative Biolabs guides you all the way from project inception to high quality results. If you have interest, please do not hesitate to contact us.

References

1. Eftang, L. L.; et al. Interleukin-8 is the single most up-regulated gene in whole genome profiling of H. pylori exposed gastric epithelial cells. BMC microbiology. 2012.
2. Barati, T.; et al. AGS cell line xenograft tumor as a suitable gastric adenocarcinoma model: growth kinetic characterization and immunohistochemistry analysis. Iranian journal of basic medical sciences. 2018, 21(7), 678–681.

For Research Use Only | Not For Clinical Use