Supported by in-house scientists and first-in-class technical platforms, Creative Biolabs is confident in providing an integrated solution for engineering ovarian cancer cell OVCAR-3 for self-destruction purposes to facilitate your project’s success.

Biological and Clinical Features of Ovarian Carcinoma

Ovarian cancer is one of the most fatal gynecologic malignancies around the world. Which is characterized by a unique tumor microenvironment that is capable of achieving specific and efficient metastatic routes, impairing immune surveillance, and mediating treatment resistance. A typical feature of ovarian cancer TME is the role of resident host cells, particularly active mesothelial cells, which line the peritoneal cavity in large numbers, and adipocytes of the omentum, the preferred site of metastatic lesions.

Fig.1 Functions of extracellular microvesicles (EVS) in ovarian cancer ascites. (Worzfeld, et al., 2017)

Engineering Ovarian Cancer Cell OVCAR-3 for Self-destruction

OVCAR-3 is a highly metastatic, drug-resistant human ovarian carcinoma cell line. OVCAR-3 cells express WT1 protein (Wilms Tumor 1 protein), a marker of high-level serous ovarian carcinoma, and it is an ideal model to study the mechanism of ovarian cancer and to search for more new therapeutic strategies. With unrivaled expertise and experiences in immune-oncology discovery and development, Creative Biolabs’ scientists are dedicated to bringing together years of valuable experience to help our clients shorten the research journey. We are committed to developing a new strategy for ovarian cancer immunotherapy study, providing an integrated solution for engineering ovarian cancer cell OVCAR-3 for self-destruction purposes to reduce the overall project development timeline for our clients.

Leveraging our professional knowledge and experience, Creative Biolabs is dedicated to offering several novel means to transfect different cytokines into ovarian cancer cell line OVCAR-3, activating the immune system to destroy cancer cells. And our scientists and technicians are experienced in every step with high dedication to ensuring accurate outcomes. More importantly, we have confidence in analyzing and optimizing the experimental scheme according to the client's project to ensure that the client's needs are met.

Moreover, we offer the following hot ovarian cancer research topic including but not limited to:

• Engineering Ovarian Cancer Cell CAOV3 for Self-destruction
• Engineering Ovarian Cancer Cell SK-OV-3 for Self-destruction
• Engineering Ovarian Cancer Cell IGROV1 for Self-destruction

For more details on our engineering ovarian cancer cell line OVCAR-3 for self-destruction, please don’t hesitate to contact us for more information. To request other related services, please feel free to contact us to discuss your project.

References

1. Luo, X.; et al. Shaping immune responses in the tumor microenvironment of ovarian cancer. Frontiers in Immunology. 2021, 12: 2383.
2. Worzfeld, T.; et al. The unique molecular and cellular microenvironment of ovarian cancer. Frontiers in oncology. 2017, 7: 24.

For Research Use Only | Not For Clinical Use