Creative Biolabs is a specialized CRO biocompany, providing a full range of oncology services to customers. Focusing on the need for innovative development of cancer immunotherapy, we leverage our experience in ferroptosis signaling pathway analysis to build a comprehensive technology platform covering key technologies for target discovery, validation studies, and preclinical studies.
Introduction to Ferroptosis Signaling Pathway
Ferroptosis is a newly discovered programmed death pattern characterized by the accumulation of lipid peroxidation and reactive oxygen species and the increase of free iron. It involves the biological processes of glutathione metabolism, iron metabolism, lipid metabolism, and oxidative stress. In recent years, a large number of studies have shown that ferroptosis is closely related to the occurrence and development of tumors, and can affect cancer development by regulating the level of intracellular iron ions and the degree of lipid peroxidation in signaling pathways. Therefore, ferroptosis and its signaling pathway can be used as tumor diagnosis, prevention, and treatment targets.
Fig.1 Schematic Description of The Signaling Pathway of Ferroptosis.1
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Inhibition of cystine/glutamate reverse transporters induced ferroptosis
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Inhibition of GPX4-induced ferroptosis
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Iron accumulation-induced ferroptosis
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Promoting ACSL4/LPCTA3/ALOX15 lipid metabolism pathway induced ferroptosis
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Inhibition of NADPH/FSP1/CoQ10 pathway induced ferroptosis
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Blocking the GCH1/BH4/DHFR pathway induced ferroptosis
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Inhibition of dihydrooriotic dehydrogenase (DHODH) pathway-induced ferroptosis
With years of research experience in oncology and ferroptosis, Creative Biolabs is capable of providing clients with a diverse range of signaling pathway analysis systems, from autophagy-related and RAS-MAPK pathways to intervene in iron metabolism, to GPX4-related pathways to regulate the signaling pathways of the antioxidant system. Moreover, We also offer ferroptosis-inducing tumor model design, construction, analysis, and validation services. Nowadays, our ferroptosis signaling pathway research platform has proven its significant role in generating new ideas for cancer immunotherapy.
Ferroptosis Signaling Pathway-Related Target Discovery solution
The occurrence of ferroptosis is suppressed in various tumors, and the induction of tumor cells represents a novel strategy for tumor drug development. Creative Biolabs has amassed nearly 800 compounds associated with the ferroptosis pathway, including GPX4, ROS, p53, and Nrf2, as well as iron chelating agents, antioxidants, and other types of small molecules to aid in the discovery, screening, identification, and drug development of targets related to the ferroptosis signaling pathway. Our ferroptosis compound products are suitable for high throughput and high content screening. We will provide comprehensive instructions, compound structure, target information, activity description, and other relevant details. Meanwhile, we will utilize NMR, HPLC/LCMS, and other advanced detection technologies to ensure the accuracy of product structure, and high purity, and minimize false positives.
In addition, we also used CRISPR screening libraries to find new targets related to ferroptosis. We can construct different screening libraries, including but not limited to, genome-wide activated library, synthetic lethal library, and metabolic gene knockout library to screen ferroptosis resistance genes in tumor cell models.
Advantages
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In vivo/in vitro overall services
Creative Biolabs has an experienced team of experts and a mature and stable ferroptosis detection technology platform, which can provide customers with the whole process services such as molecular screening of ferroptosis signaling pathway, tumor ferroptosis design, animal tumor model construction, and in vitro/in vivo efficacy evaluation.
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Mature signal pathway target screening platform
Our platform is based on massive amounts of second-generation sequencing and oncology data. By using machine learning and deep learning algorithm models, the ferroptosis-related gene data-assisted diagnosis system represented by mutation pathogenicity prediction and mutation shear change prediction has been successfully established.
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Extensive library of tumor mouse models
The mouse model is an important model for ferroptosis-inducing tumor model evaluation, so Creative Biolabs has developed a set of severely immunodeficient mice and humanized immune mice to ensure that can provide a wide range of in vivo pharmacodynamic evaluation in various tumor types.
Creative Biolabs is committed to developing the world's first and best-in-class ferroptosis-inducing tumor analysis technology platform. Since its inception, the company has been committed to building a fully integrated in-house development capability and visionary development of an end-to-end oncology service chain covering target discovery, validation, and signaling pathway analysis. If you have any special needs in our ferroptosis signaling pathway-related target services or are interested in learning more about our company, please feel free to contact us for more details.
Reference
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Yan, Hong-fa, et al. "Ferroptosis: mechanisms and links with diseases." Signal transduction and targeted therapy 6.1 (2021): 49.
For Research Use Only | Not For Clinical Use
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