FH-Bind™ Platform

Immune system has the potential for the specific destruction of tumors without toxicity to normal tissues and immuno-oncology is the research and development of a therapy that takes advantage of the body's immune system to fight against cancer. As an excellent and outstanding team in immunomodulatory therapies, Creative Biolabs launches the proprietary FH-Bind™ platform to improve the response rate of immune therapy.

Introduction of FH-Bind™ Platform

Natural human serum albumin (HSA), the predominant protein in blood plasma, exists in the bloodstream. The albumin could accumulate at sites of inflammation, including tumors. A fully human albumin binding construct binds to endogenous HSA in the bloodstream, resulting in significantly enhanced half-life which means remaining longer in the body. It naturally accumulates at sites of inflammation, including tumors, and then is transported to the target tissues.

FH-Bind™ platform provides considerable payload flexibility with asset generation capabilities across major biologic drug classes. Moreover, FH-Bind™ is characterized as fully human, with a human glycosylation profile that can be manufactured using a standard CHO process. The versatile platform can generate a large immune-oncology pipeline, including combinations of two therapeutic cancer products into one synergistic product.

Fig.1 Pre-incubation of FH with human IAV strains alters virus entry to human lung cells. (Rabeeah, Iman, et al, 2024)Fig.1 Pre-incubation of FH with human IAV strains alters virus entry to human lung cells.1

Characteristics of FH-Bind™ Platform

Services

FH-Bind™ is the foundation of a modular, plug-and-play drug development platform with the following distinct advantages:

Our pipeline platform comprises a lot of cytokine-derived therapeutic candidates, including IL-6 therapeutic candidates.

Creative Biolabs is the best choice for the development of immunomodulatory therapies. With an experienced expert team and deep knowledge of biopharmaceutical drug discovery and development, we launch the proprietary FH-Bind™ technology to empower the development of innovative targeted biologic drugs. If you are interested in the FH-Bind™ platform, please contact us or directly send us an inquiry.

Reference

  1. Rabeeah, Iman, et al. "Mapping the interaction sites of human and avian influenza A viruses and complement factor H." Frontiers in Immunology 15 (2024): 1352022.

For Research Use Only | Not For Clinical Use

Online Inquiry
Copyright © 2024 Creative Biolabs. All Rights Reserved.
ISO 9001 Certified - Creative Biolabs Quality Management System.