Short Decsription
This product is a GSK-3-targeted RNA modification and metabolomics analysis tool based on the m6A (METTL14-YTHDF2-ALKBH5-HDACs-Thiol) modification and Glycogen synthesis-mediated (TDP-43-SAM-NAD+) metabolic analysis system.
Oligonucleotide
PS, 2'-OMe, 2'-F, GalNAc
RNA Construction
tRNA-m6A-METTL14-YTHDF2-ALKBH5-HDACs-Thiol
Pathway
Glycogen synthesis
Epigenetic regulator
SMARCA4 deficiency
Metabolic alteration
Upregulating oxidative phosphorylation
Targeting diseases
Gastric Cancers
RNA-binding proteins
TDP-43
Metabolic Reprogramming
Glycogen synthesis-TDP-43-SAM-NAD+