Immune Cells Function Assay

In the search for accurate cancer treatment, scientists are developing new technologies, known as immuno-oncology, that use the body's natural defenses to target and eradicate cancer cells. Over the past decade, immune cell function assay has become a critical step in cancer treatment due to its specificity, adaptability and durability.

However, the development of new immunotherapies still faces many challenges. Proper tools are needed to accurately track the dynamic interaction of immune cells in this highly complex tumor microenvironment.

The living cell analysis technology developed by Creative Biolabs is such a tool that can be used for in vitro analysis to study the dynamics of immune cells. We also offer a wide range of assays and platforms for in vitro detection of immunodominant drugs, including immunophenotyping, functional assays and tumor microenvironmental regulation analysis, allowing you to confidently move on to the next phase of drug development.

In Vitro Immune Cell Function Assays

Fig1. Immune cells and the tumor vasculature in the tumor. (Stockmann, 2014)

T Cell Targets and Activation

• T cell target and activation
• T cell proliferation
• Target expression profiling on T cell subsets
• Screening assay to enhance proliferation and survival (MLR)
• Regulation of differentiation and cytokine profiles
• Immune cell migration assay
• Antigen-specific recall response assay
• Screening for the ability to reverse T cell exhaustion
• Suppression assay using regulatory T cells
• Mixed lymphocyte reaction (PBMC / T cell / DC, one-way or two-way)
• Immune checkpoint blocking assay
• Cytokine secretion profile (ELISA, Luminex, ELISpot)
• T cell surface marker expression analysis (flow cytometry)

For more details, please feel free to contact us or send us a query directly.

Reference

1. Stockmann C.; et al. The impact of the immune system on tumor: angiogenesis and vascular remodeling. Frontiers in Oncology. 2014, 4:69.

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