Creative Biolabs is a customized immunology CRO company with in-depth knowledge of immune mechanisms and cancer research, providing you with excellent services in the design, development, and validation of preclinical models (ex vivo and in vitro) to study immune interactions.

Introduction to Immune Modelling & Experimental Design

The study of experimental immunology usually involves complex immune responses. To date, no comprehensive analytical system has been discovered to fully reveal these mechanisms. Therefore, it is particularly important to establish a special model to design the experiment. Considering various cell-cell interactions, immunogenicity, and tolerability of drugs, Creative Biolabs has developed an immune modeling & experimental design platform focused on providing services for immune response studies and ex vivo and in vitro human system modeling. Currently, our Immune models have been considered a powerful tool for discovering or testing potential oncology drugs against autoimmune or adverse immune responses.

Fig.1 Experimental Design of Disease Models in Mice.¹

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Immunotherapy is undoubtedly the focus of current research in the field of tumor therapy, and whether to study immune checkpoints or evaluate the effect of cell therapy, finding a suitable mouse model that can simulate the human immune system is the key. As a result, the immunotherapy target gene humanized mouse model, immune deficiency mouse model, and immune system humanized mouse model have become an essential tool in our labs.

Nowadays, we have more than 100 humanized mouse strains (including two-target, three-target, and four-target humanized mice), and our model resource library covers the latest and hottest immunotherapy targets, which can significantly reduce research costs, save research time, and efficiently obtain reliable experimental data.

With the continuous advancement of gene editing technology, our labs have successfully constructed a wide range of immunodeficient mouse models. Based on the client's project requirements, we can provide additional support in designing specific immune deficiency models, including investigating the growth characteristics of tumor cells after inoculation and conducting studies related to immunology or oncology. Our expert team of immune response assessment scientists will work closely with you to provide expert immune modeling and experimental design strategies to address your specific experimental analysis needs.

Fig.2 PDX Model Design.²

Case Study: Patient-derived Xenografts (PDX) Model for Cancer Immunotherapy

PDX is a common mouse model used in our lab to test the effects of novel anticancer drugs. When we use PDX, a well-established immune system environment will be generated to get the most accurate immunotherapy evaluation data. in general, we will use models of immune deficiency or only partially immunoreactive hosts for testing. These models are simple and can directly reflect the differences between human biological agents and mouse tumor immune models. We then implant the human immune system into humanized mice to further correctly simulate the human immune system response and disease symptoms. For the validation analysis, blood samples from 3-4 normal healthy donors will be used for mouse model evaluation. Whole blood will be collected for analysis at 14, 28, and 42 days after administration. Normally, tumor growth, body weight, and GVHD-like features will be further evaluated.

Why Choose Us?

• A high level of human-reconstructed humanized mouse models can be designed.
• Through the design and modification of immunogens, and whole-human monoclonal antibodies platform has been established.
• By optimizing cytokine environment and antigen presentation efficiency, adaptive immune T cells that can strongly kill tumors can be obtained.
• Constantly explore new tumor immunotherapy strategies and immune modeling methods.

By continuing to grow in response to the requirements of our clients, Creative Biolabs is dedicated to exploring novel and innovative immune modeling technologies to offer the most comprehensive, integrated portfolio of cancer Immunotherapy solutions. If you are interested in our services, please feel free to contact us for closer communication to learn how we can be involved in your project. Separate services or integrated end-to-end solutions are all welcomed.

References

1. Tao, L.; et al. Making mouse models that reflect human immune responses. Trends in immunology, 2017, 38(3): 181-193.
2. Liu, Y.; et al. Patient-derived xenograft models in cancer therapy: technologies and applications. Signal Transduction and Targeted Therapy, 2023, 38(1): 160.

For Research Use Only | Not For Clinical Use