Immunosuppressive Cytokine-based Cancer Immunotherapy

Immunosuppressive cytokines play a crucial role in the tumor immune microenvironment. These cytokines limit the proliferation and effector functions of anti-tumor immune cells, alter their plasticity, and convert them into an inhibitory phenotype. Targeting or depleting the corresponding immunosuppressive cytokines has significant clinical benefits. Studies have shown that several cytokines play immunosuppressive roles in tumorigenesis, depending on the tumor type and tumor immune environment. Creative Biolabs provides a variety of immunosuppressive cytokine design strategies to safely and effectively modulate cytokine activity for therapeutic purposes.

Type of Immunosuppressive Cytokines

Fig.1 Immunosuppressive cytokines in promoting tumor growth.¹

These immunosuppressive cytokines play an important role in limiting anti-tumor immunity and tumor growth progression. By blocking immunosuppressive cytokines, such as IL-10, TGF-β and IL-35, anti-tumor immunity can be activated and tumorigenesis can be controlled.

Our Service

Creative Biolabs provides a range of cytokine-based cancer immunotherapy development services. We inhibit cytokine activity through various cytokine alteration strategies, including but not limited to:

• Inhibits JAKs and STATs

In addition to regulating cytokine signaling through mutations, inhibitors, and some agonists, targeting signaling molecules is another important way to regulate cytokine activity. Inhibition of JAK is now widely used as a treatment. The figure below illustrates the antitumor and immunosuppressive effects of JAK inhibitors. STAT proteins mediate the action of cytokines, and selective inhibition of one of the STAT proteins can shift the balance to another phenotype.

Fig.2 Schematic diagram of antitumor and immunosuppressive effects of AK inhibitors.2

Prospect and Future

Cytokines play a key regulatory role in many biological processes, and their production and activity are tightly regulated to maintain homeostasis. Over the years, Creative Biolabs has developed a deeper understanding of the structure of cytokines and cytokine receptors, receptor biology, and mechanisms of intracellular signaling. In order to achieve therapeutic effects, we apply a variety of methods to intervene in the action of cytokines. Based on a team of experienced scientists and an innovative technology platform, we will uphold a scientific attitude and professional capabilities to escort your research projects.

If you have any questions about the immunosuppressive cytokine-based cancer immunotherapy services, please contact us directly. Our professional technicians are at your service around the clock!

References

1. Mirlekar, Bhalchandra. "Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: Its implications in cancer immunotherapy." SAGE open medicine. (2022) 10 20503121211069012.
2. Klein, Klara.; et al. "Untwining anti-tumor and immunosuppressive effects of JAK inhibitors-A strategy for hematological malignancies?" Cancers. 2021. 13, no. 11: 2611.
3. Sun, Xiuyun.; et al. "PROTACs: great opportunities for academia and industry." Signal transduction and targeted therapy. (2019) 4 64.

For Research Use Only | Not For Clinical Use