Overview

While in vitro cell models provide valuable insights into tumor cell metabolism, studying the metabolism of tumor cells in the body is a closer approximation to the actual situation. Therefore, studying metabolism in vivo is a crucial step in understanding actual tumor metabolism. At Creative Biolabs, we offer various tools and services to support your research on tumor metabolism. Our team of experts provides various noninvasive imaging modalities to quantitatively measure tumor metabolism in animal models. Our methods include positron emission tomography and computed tomography (PET-CT), micro CT, magnetic resonance imaging (MRI), and optical imaging.

Fig.1 Different imaging modalities for the detection of major metabolic pathways.¹

Our Services

We can assist you with the following:

• In Vivo Isotope Tracing for Tumor Metabolism

Isotope tracing in vivo is a technology used to study tumor cell metabolism. This technology utilizes nutrients with isotope marks. When these isotope-marked nutrients enter tumor cells, they are used to synthesize biomolecular molecules, thereby revealing the metabolic pathway of tumor cells. Combined with imaging technologies such as positron emission tomography (PET) or magnetic resonance imaging (MRI), isotope tracing can provide a more comprehensive understanding of tumor biology. At Creative Biolabs, we have a professional team with rich experience in isotope tracing technology. We utilize various technologies to trace the metabolic process of tumor cells in vivo.

• Metabolism-based Fluorescent Imaging

Metabolic fluorescent imaging is a technology used to study tumor cell metabolism. This technology utilizes a fluorescent dye to label metabolites, which will emit fluorescence under a specific wavelength. By observing the fluorescence of these dyes, the metabolic status and pathway of tumor cells can be revealed. This technique provides a non-invasive method to study tumor cell metabolism in real-time, allowing for a more comprehensive understanding of the disease process. At Creative Biolabs, we use a range of fluorescent dyes to label metabolites. We are committed to the continuous improvement of our metabolic fluorescent imaging techniques to provide clients with the best results.

• Diet-Induced Obesity (DIO) Mouse Model for In Vivo Metabolism Study

At Creative Biolabs, we employ the Diet-Induced Obesity (DIO) Mouse Model, a robust and reliable method to study obesity and related metabolic conditions. This endorsed model provides replicable insights into the onset and progression of obesity, offering valuable data for potential therapeutic interventions.

Advantages

• We provide one-stop tumor metabolism analysis services to help you comprehensive and systematic understanding of tumor metabolism.
• We help you choose the most suitable probes and tracers specifically for your research needs.
• Our team of experts can help you design and execute your research project using the most appropriate imaging modality and analysis methods.
• We provide consultation services to help you interpret the data and develop a better understanding of tumor metabolism in vivo.

Contact us today to learn more about how we can help you with your research.

Reference

1. Momcilovic, Milica, and David B. Shackelford. "Imaging cancer metabolism." Biomolecules & therapeutics 26.1 (2018): 81.

For Research Use Only | Not For Clinical Use