Heating™ Inducing Immunogenic Tumor Cell Death to Heating Up Cold Tumors
Turning 'Cold' Tumors into 'Hot' Tumors
Immune checkpoints refer to inhibitory pathways on the surface of T cells that suppress immune activation. As a common tumor immunotherapy, immune checkpoint inhibitors (ICIs) reactivate the T cell immune response to tumors by inhibiting immune checkpoint activity, thereby achieving anti-tumor effects.
Fig.1 Application of immune checkpoints in cancer immunotherapy.1
In "hot" tumors, immune cells are more active, and their internal environment is also invaded by a large number of T cells, and when the inhibitory effect of immune checkpoints is lifted by ICIs, the immune response effect of T cells to the tumor is activated again, and the activated T cells kill cancer cells and play an immunotherapeutic role. As a result, "hot tumors" with an inflammatory phenotype tend to be more sensitive to ICIs. For "cold tumors", it is difficult for immune cells to recognize and kill, and it is difficult for immune checkpoint inhibitors to function. Creative Biolabs provides a variety of services to induce immunogenic tumor cell death to transform "cold tumors" into "hot tumors", improving the response rate and treatment effect of tumor immunotherapy.
Our Service
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Promote T cell initiation
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What We Can Offer
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Description
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Application
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Immune adjuvants
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Immune adjuvants are a class of auxiliary substances that, when combined with antigens, can enhance the body's immune response to antigens or change the type of immune response.
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Freund's adjuvant and cytokine adjuvant
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Oncolytic viruses (OVs)
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OVs are a class of replication-capable tumor-killing viruses. In addition to selective tumor lysis, they can activate innate and adaptive immune responses that alter TME.
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ICIs combination
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Thermal ablation therapy
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This method uses the biological effect of heat to cause irreversible damage or coagulation necrosis of tumor cells in diseased tissues.
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Chemotherapy; Radiotherapy; ICIs combination
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Chemoradiotherapy
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The method includes chemotherapy and radiation therapy. Radiotherapy promotes the transport of effector T lymphocytes to the tumor site by inducing tumor cell expression and chemokine release. Chemotherapy drugs can exert immunostimulatory effects by enhancing immunogenicity and increasing T cell infiltration.
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Radiofrequency Ablation (RFA); Laser Ablation (LA); Microwave ablation (MWA); High Intensity Focused Ultrasound (HIFU) Ablation
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Published Data
The cGAS-STING signaling pathway is a major component of the innate immune system and has the effect of promoting the transformation of the tumor microenvironment from "cold" tumors to "hot" tumors. The STING agonist action and the ICI action are complementary and synergistic.
Fig.2 cGAS-STING pathway.2
Studies have shown that STING agonist 4c can significantly reduce tumor volume and effectively inhibit the growth of mouse tumor cells in a CT26 mouse colorectal cancer model. In addition, in the 4C-treated mouse model, the growth of relapsed tumors was also inhibited in the absence of secondary administration due to immune memory. These results suggest that 4c has the potential to enable cancer immunotherapy through STING-mediated immune activation.
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Increase the number of antigen-specific T cells
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What We Can Offer
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Description
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Application
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Adoptive Cell Therapy (ACT)
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This method refers to isolating immune active cells, amplifying and functionally identifying them in vitro, and then infusing them into the body, thereby achieving the purpose of directly killing tumors or stimulating immune responses in the body to kill tumor cells.
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Tumor-infiltrating lymphocytes (TILs); chimeric antigen receptors (CAR-T); and natural killer cells (NK)
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Cancer vaccines
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Therapeutic vaccines have become an emerging immunotherapy modality by expanding the tumor-specific T cell pool and increasing the transport of T lymphocytes to the tumor region.
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Combined with immune checkpoint blockade
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Creative Biolabs offers clients a range of services related to promoting T cell initiation, increasing the number of antigen-specific T cells, facilitating T cell transport and infiltration, and a range of nanotechnology-based cold tumor heating. You can click on Targeting the Tumor Microenvironment and Nanomedicine Development Service units to find more!
Or you can get in touch with our technicians directly, and scientists at Creative Biolabs are available 24 hours a day to provide you with the appropriate services and information.
References
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Gujar, Shashi.; et al. "Heating it up: oncolytic viruses make tumors 'hot' and suitable for checkpoint blockade immunotherapies." Oncoimmunology. (2018) 7,8 e1442169.
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Gan, Yu.; et al. "The cGAS/STING pathway: A novel target for cancer therapy." Frontiers in immunology. (2022) 12 795401.
For Research Use Only | Not For Clinical Use
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